VOAR 3.0 : a Configurable Environment for Manipulating Multiple Ontology Alignments
, 2017 Bernardo Severo +2 more
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Advanced Science, EarlyView.Lipopolysaccharide induces upregulation of the magnesium (Mg2+) efflux transporter solute carrier family 41 member 1 in dental stem cells, leading to a decrease in intracellular Mg2+ concentration and promoting the binding of oligomycin sensitivity‐conferring protein and cyclophilinD.
Yuan Liu +11 more
wiley +1 more source
The Onto-Rhythmic Self: An Ontological Reframing of Subjectivity. [PDF]
Integr Psychol Behav SciRahimi MD.
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Advanced Science, EarlyView.In temporal lobe epilepsy, hippocampal APOE is markedly upregulated predominantly in microglia. APOE overexpression in microglia drives TLR4 and cGAS/STING‐dependent neuroinflammation, engages bidirectional crosstalk with neurons and astrocytes, increases neuronal excitability, and perturbs hippocampal lipid metabolism. These findings suggest that APOE‐
Jianwei Shi +10 more
wiley +1 more source
Vascular-type heterogeneity is associated with differential gene expression profiles of endothelial cells under shear stress. [PDF]
Res Pract Thromb HaemostCox AA, Ng CJ.
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Identifying Tipping Points during Healthy Brain Aging through Single‐Nucleus Transcriptomic Analysis
Advanced Science, EarlyView.This study applies single‐nucleus transcriptomics and systems dynamics to uncover nonlinear aging patterns in healthy human brains. By introducing dynamic network biomarker theory, the authors identify a critical tipping point at ages 56–60 during aging, and highlight glial instability as a key mediator.
Peiru Wu +9 more
wiley +1 more source
Ontology-Based Modelling and Analysis of Sustainable Polymer Systems: PVC Comparative Polymer and Implementation Perspectives. [PDF]
Polymers (Basel)Chidara A, Cheng K, Gallear D.
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Results of the Ontology Alignment Evaluation Initiative 2018
, 2018 Mina Abd Nikooie Pour +34 more
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Human Brain Cell‐Type‐Specific Aging Clocks Based on Single‐Nuclei Transcriptomics
Advanced Science, EarlyView.Muralidharan and colleagues develop cell‐type‐specific transcriptomic aging clocks using single‐nucleus RNA sequencing of human post mortem prefrontal cortex samples. These clocks accurately predict age and identify distinct aging trajectories in specific brain cell types.
Chandramouli Muralidharan +12 more
wiley +1 more source
Integrating knowledge graphs with ancient Chinese medicine classics: challenges and future prospects of multi-agent system convergence. [PDF]
Chin MedXiang S, Lin H, Cai F, Jiang Z.
europepmc +1 more source