Results 41 to 50 of about 3,408 (243)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Results of the ontology alignment evaluation initiative 2018

, 2022
76116The Ontology Alignment Evaluation Initiative (OAEI) aims at comparing ontology matching systems on precisely defined test cases. These test cases can be based on ontologies of different levels of complexity (from simple thesauri to expressive OWL ...
Ferrara, A., Jimenez-Ruiz, E., Schmidt, D., Karam, N., Saveta, T., Paulheim, H., Thieblin, E., Zamazal, O., Faria, D., Zhou, L., Hertling, S., Cheatham, M., Vatascinová, J., Shvaiko, P., Fundulaki, I., Khiat, A., Trojahn, C., Pesquita, C., Algergawy, A., Harrow, I., Splendiani, A., Lambrix, P., Li, H., Montanelli, S.   +23 more
core  

Interactive Cross-Lingual Ontology Matching

IEEE Access, 2019
Recently, with the growing number of ontologies defined in different languages, to bridge the semantic gaps between them, it is necessary to identify the correspondences between their heterogeneous entities, so-called cross-lingual ontology matching. Due
Junfeng Chen, Xingsi Xue, Yikun Huang, Xuewu Zhang   +3 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Results from experiments in ontology learning including evaluation and recommendation [PDF]

, 2007
This document describes the Ontology Learning experiments we performed in order to recommend a set of ontology learning techniques to enhance the ontology engineering process in the fisheries domain in place at FAO. Experiments have been conceived in the
Caracciolo, Caterina, D'Aquin, Mathieu, Sabou, Marta, Voelker, Johanna, Peters, Wim   +4 more
core  

Results of the ontology alignment evaluation initiative 2020

, 2022
92138The Ontology Alignment Evaluation Initiative (OAEI) aims at com-paring ontology matching systems on precisely defined test cases. These testcases can be based on ontologies of different levels of complexity and use different evaluation modalities (e.
Lambrix, Patrick, Khiat, Abderrahmane, Vatascinová, Jana, Hertling, Sven, Splendiani, Andrea, Li, Huanyu, Thiéblin, Elodie, Faria, Daniel, Trojahn, Cássia, Algergawy, Alsayed, Karam, Naouel, Laadhar, Amir, Shvaiko, Pavel, Saveta, Tzanina, Harrow, Ian, Fundulaki, Irini, Paulheim, Heiko, Jiménez-Ruiz, Ernesto, Yaman, Beyza, Zamazal, Ondrej, Jonquet, Clement, Zhou, Lu, Amini, Reihaneh, Li, Ying, Nikooie Pour, Mina Abd, Pesquita, Catia, Hitzler, Pascal   +26 more
core  

Results of the Ontology Alignment Evaluation Initiative 2015. [PDF]

, 2015
Ontology matching consists of finding correspondences between semantically related entities of two ontologies. OAEI campaigns aim at comparing ontology matching systems on precisely defined test cases. These test cases can use ontologies of different nature (from simple thesauri to expressive OWL ontologies) and use different modalities, e.g., blind ...
Cheatham, Michelle, Dragisic, Zlatan, Euzenat, Jérôme, Faria, Daniel, Ferrara, Alfio, Flouris, Giorgos, Fundulaki, Irini, Leitzke Granada, Roger, Ivanova, Valentina, Jiménez-Ruiz, Ernesto, Lambrix, Patrick, Montanelli, Stefano, Pesquita, Catia, Saveta, Tzanina, Shvaiko, Pavel, Solimando, Alessandro, Trojahn dos Santos, Cassia, Zamazal, Ondrej   +17 more
openaire   +2 more sources

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Argumentation over Ontology Correspondences in MAS [PDF]

, 2007
In order to support semantic interoperation in open environments, where agents can dynamically join or leave and no prior assumption can be made on the ontologies to align, the different agents involved need to agree on the semantics of the terms used ...
Trevor Bench-Capon, Terry Payne, Payne, Terry R., Euzenat, Jerome, Payne, Terry, Bench-Capon, Trevor, Ian Blacoe, Jerôme Euzenat, Loredana Laera, Tamma, Valentina, Valentina Tamma, Laera, Loredana, Blacoe, Ian   +12 more
core   +1 more source