Results 81 to 90 of about 43,195 (259)

Extracellular Vesicles Modulation by an Adiponectin Receptor Agonist Provides Cardioprotection for Myocardial Ischemic Injury

Advanced Healthcare Materials, EarlyView.
This study demonstrates that ALY688, a drug mimicking the heart‐protective hormone adiponectin, reduces myocardial ischemia injury. ALY688 increases the production of extracellular vesicles, which carry protective cargo including adiponectin itself.
Jialing Tang, Wing Yan Chung, Serena M. Pulente, Yubin Lei, Khang Nguyen, Eddie Tam, Nadya M. Morrow, Ilka Lorenzen‐Schmidt, Fengxia Xiao, Augusto Zani, Dylan Burger, Hye Kyoung Sung, Erin E. Mulvihill, Gary Sweeney   +13 more
wiley   +1 more source

National Center for Biomedical Ontology: Advancing biomedicine through structured organization of scientific knowledge [PDF]

, 2006
The National Center for Biomedical Ontology is a consortium that comprises leading informaticians, biologists, clinicians, and ontologists, funded by the National Institutes of Health (NIH) Roadmap, to develop innovative technology and methods that allow
Chute, Christopher G., Lewis, Suzanna E., Michael, Ashburner, Monte, Westerfield, Mungall, Chris J., Musen, Mark A., Noy, Natasha, Richter, John D., Rubin, Daniel L., Sim, Ida, Sima, Misra, Smith, Barry, Solbrig, Harold, Storey, M. A.   +13 more
core   +2 more sources

Bottom‐Up Programming of Cell States in Cancer Organoids with Defined Synthetic Adhesion Cues

Advanced Materials, EarlyView.
A bottom‐up biomaterial platform is developed to program transcriptomic states in pancreatic cancer organoids by tuning adhesion cues within synthetic matrices. By combining a Design of Experiments framework with multiobjective optimization, matrix compositions are identified that enrich specific cellular programs like EMT.
Ali Nadernezhad, Verena J. Kast, Dagmar Pette, Franziska Baenke, Daniel E. Stange, Carsten Werner, Daniela Loessner   +6 more
wiley   +1 more source

Introducing fuzzy trust for managing belief conflict over semantic web data [PDF]

, 2008
Interpreting Semantic Web Data by different human experts can end up in scenarios, where each expert comes up with different and conflicting ideas what a concept can mean and how they relate to other concepts. Software agents that operate on the Semantic
Motta, Enrico, Nagy, Miklos, Vargas-Vera, Maria   +2 more
core   +1 more source

Grid service discovery with rough sets [PDF]

, 2008
Copyright [2008] IEEE. This material is posted here with permission of the IEEE. Such permission of the IEEE does not in any way imply IEEE endorsement of any of Brunel University's products or services.
Bin Yu, Maozhen Li, Omer Rana, Senior Member, Zidong Wang   +4 more
core   +2 more sources

Results of the Ontology Alignment Evaluation Initiative 2010

, 2010
Ontology matching consists of finding correspondences between entities of two ontologies. OAEI campaigns aim at comparing ontology matching systems on precisely defined test cases. Test cases can use ontologies of different nature (from simple directories to expressive OWL ontologies) and use different modalities, e.g., blind evaluation, open ...
Euzenat, Jérôme, Ferrara, Alfio, Meilicke, Christian, Nikolov, Andriy, Pane, Juan, Scharffe, François, Shvaiko, Pavel, Stuckenschmidt, Heiner, Sváb-Zamazal, Ondrej, Svátek, Vojtech, Trojahn dos Santos, Cassia   +10 more
openaire   +3 more sources

A Nano‐Interception Strategy for Chronic Heart Failure: Prussian Blue Nanoparticles Disrupt Fibroblast‐Immune Communication via CCL2 Sequestration

Advanced Materials, EarlyView.
A nano‐interception strategy disrupts pathogenic fibroblast–macrophage crosstalk in chronic heart failure. Scalable Prussian blue nanoparticles selectively sequester CCL2 via ultrahigh‐affinity binding, preventing CCR2+ macrophage recruitment and breaking a key fibro‐inflammatory circuit. This approach demonstrates robust efficacy in murine and porcine
Bo Chen, Gao Wei, Guowei Zeng, Haoyu Li, Rongrong Wu, Hongyu Yan, Zijie Zhou, Kai Luo, Xiaoyang Zhang, Cong Li, Longming Huang, Lingyan Cheng, Xinjie Zhang, Jinghao Zheng, Bozhong Shi, Xiaojun Cai, Xiaomin He   +16 more
wiley   +1 more source

Results of the Ontology Alignment Evaluation Initiative 2009

, 2009
Ontology matching consists of finding correspondences between on- tology entities. OAEI campaigns aim at comparing ontology matching systems on precisely defined test cases. Test cases can use ontologies of different nature (from expressive OWL ontologies to simple directories) and use different modal- ities, e.g., blind evaluation, open evaluation ...
Euzenat, Jérôme, Ferrara, Alfio, Hollink, Laura, Isaac, Antoine, Joslyn, Cliff, Malaisé, Véronique, Meilicke, Christian, Nikolov, Andriy, Pane, Juan, Sabou, Marta, Scharffe, François, Shvaiko, Pavel, Spiliopoulos, Vassilis, Stuckenschmidt, Heiner, Sváb-Zamazal, Ondrej, Svátek, Vojtech, Trojahn dos Santos, Cassia, Vouros, George, Wang, Shenghui   +18 more
openaire   +4 more sources

Breaking-down the Ontology Alignment Task with a Lexical Index and Neural Embeddings [PDF]

Large ontologies still pose serious challenges to state-of-the-art ontology alignment systems. In the paper we present an approach that combines a lexical index, a neural embedding model and locality modules to effectively divide an input ontology ...
Agibetov, A., Cross, V., Jimenez-Ruiz, E., Samwald, M.   +3 more
core  

Matrix Viscoelasticity Regulates Dendritic Cell Migration and Immune Priming

Advanced Materials, EarlyView.
Matrix viscoelasticity is a key mechanical feature of the tumor microenvironment but remains poorly understood in immune regulation. Here, we develop a tunable collagen platform to decouple viscoelasticity from stiffness and show that slow‐relaxing matrices constrain dendritic cell migration by limiting actomyosin‐driven matrix remodeling, thereby ...
Wei‐Hung Jung, Emie Humann, Joshua M. Price, Yoav Binenbaum, Azra Haseki, Sanjana Iyer, David J. Mooney   +6 more
wiley   +1 more source