Results 91 to 100 of about 2,679,814 (347)
KNOWLEDGE ENGINEERING METHODS IN DISTRIBUTED EDUCATIONAL CONTENT DESIGN
Открытое образование (Москва), 2016 Educational content is considered by authors as a distributed system of learning objects, that are self-contained, interoperable, and reusable in multiple contexts.
Galina N. Boychenko +1 more
doaj +1 more source
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective This study aimed to systematically observe the clinical manifestations, immune cell subsets, and dynamic changes in serological indicators in patients with myasthenia gravis (MG) before and after efgartigimod (EFG) treatment. Methods We analyzed the baseline data, laboratory parameters, and lymphocyte subset proportions in MG ...
Tiancheng Luo +9 more
wiley +1 more source
Discovery and Targeted Proteomic Studies Reveal Striatal Markers Validated for Huntington's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Clinical trials for Huntington's disease (HD) enrolling persons before clinical motor diagnosis (CMD) lack validated biomarkers. This study aimed to conduct an unbiased discovery analysis and a targeted examination of proteomic biomarkers scrutinized by clinical validation. Methods Cerebrospinal fluid was obtained from PREDICT‐HD and
Daniel Chelsky +8 more
wiley +1 more source
Developmental, Neuroanatomical and Cellular Expression of Genes Causing Dystonia
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Dystonia is one of the most common movement disorders, with variants in multiple genes identified as causative. However, an understanding of which developmental stages, brain regions, and cell types are most relevant is crucial for developing relevant disease models and therapeutics.
Darren Cameron +5 more
wiley +1 more source
Ciência da Informação, 2008 O artigo se propõe a apresentar um estudo analítico sobre metodologias e métodos para construção de ontologias e vocabulários controlados através da análise da literatura sobre metodologias para construção de ontologias e de normas internacionais para ...
Daniela Lucas da Silva +2 more
doaj +1 more source
Ketogenic Diet as an Epigenetic Therapy in SETD1B‐Related Epilepsy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Histone lysine methyltransferases such as SETD1B regulate chromatin structure and gene transcription. Ketone bodies, including butyrate, act as histone deacetylase inhibitors. We report a 4‐year‐old boy with SETD1B‐related absence epilepsy, refractory to conventional medications, who achieved sustained > 90% seizure reduction on the Modified ...
Erica Tsang +10 more
wiley +1 more source
Application of Ontology Engineering in Satellite Network Simulation [PDF]
, 2013 Lin Qi, Yong Chen
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Arthritis Care &Research, EarlyView.Objective A leading cause of death among patients with scleroderma (SSc), interstitial lung disease (ILD) remains challenging to prognosticate. The discovery of biomarkers that accurately determine which patients would benefit from close monitoring and aggressive therapy would be an essential clinical tool.
Cristina M. Padilla +13 more
wiley +1 more source
A Community Network Ontology for Participatory Collaboration Mapping: Towards Collective Impact
Information, 2018 Addressing societal wicked problems requires collaboration across many different community networks. In order for community networks to scale up their collaboration and increase their collective impact, they require a process of inter-communal ...
Aldo de Moor
doaj +1 more source
Enabling Knowledge Sharing within e-Government Back-Office through Ontological Engineering [PDF]
, 2007 Graciela Brusa +2 more
openalex +1 more source