Results 81 to 90 of about 2,679,814 (347)
FEBS Open Bio, EarlyView.dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon +6 more
wiley +1 more source
Ontology Engineering to Model the European Cultural Heritage: The Case of Cultural Gems [PDF]
, 2023 Valentina Alberti +4 more
openalex +1 more source
FEBS Open Bio, EarlyView.A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li +8 more
wiley +1 more source
LOT: An industrial oriented ontology engineering framework
Engineering applications of artificial intelligence, 2022 M. Poveda-Villalón +3 more
semanticscholar +1 more source
FEBS Open Bio, EarlyView.The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida +6 more
wiley +1 more source
Advancing STEM education research with ontology
Disciplinary and Interdisciplinary Science Education ResearchResearch in STEM education is rapidly growing. Many terms in use have no shared meanings, making knowledge dissemination and accumulation difficult, if not impossible.
Xiufeng Liu +3 more
doaj +1 more source
An Ontology-Based Approach Toward Traceable Behavior Specifications in Automated Driving
IEEE AccessAutomated vehicles in public traffic are subject to a number of expectations: Among other aspects, their behavior should be safe, conforming to the rules of the road and provide mobility to their users.
Nayel Fabian Salem +6 more
doaj +1 more source
Effective medical center finding during COVID-19 pandemic using a spatial DSS centered on ontology engineering. [PDF]
GeoJournal, 2023 Rezaei Z, Vahidnia MH.
europepmc +1 more source
FEBS Open Bio, EarlyView.Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu +10 more
wiley +1 more source