Results 191 to 200 of about 269,978 (302)

Linking behaviour change techniques to mechanisms of action: Using the Theory and Techniques Tool alongside the Behaviour Change Intervention Ontology. [PDF]

Wellcome Open Res
Zhang L, Schenk PM, Santilli M, Wright AJ, Marques MM, Johnston M, West R, Michie S.   +7 more
europepmc   +1 more source

Anti‐Apoptotic and Neurite‐Protective Nanomedicine Augments Embryonic Stem Cells‐Derived Retinal Ganglion Cell Transplantation in Glaucoma Recovery

Advanced Science, EarlyView.
Lithium‐epigallocatechin gallate nanoparticles (Li‐EGCG NPs) are co‐transplanted with embryonic stem cell‐derived retinal ganglion cells (ESC‐RGCs) to enhance cell survival and therapeutic efficacy in an acute pathological glaucomatous injury model. This synergistic approach protects RGC cells, preserves retinal structure and improves visual function ...
Moxin Chen, Xiaoyan Jiang, Yuanhui Wang, Zhaobin Luo, Yu Zhang, Siwei Liu, Rui Huang, Dandan Zhang, Zhimin Tang, Yahan Ju, Shaohui Pan, Ni Ni, Wei Feng, Yu Chen, Ping Gu   +14 more
wiley   +1 more source

Transforming oncology clinical trial matching through neuro-symbolic, multi-agent AI and an oncology-specific knowledge graph: a prospective evaluation in 3804 patients. [PDF]

ESMO Real World Data Digit Oncol
Loaiza-Bonilla A, Yost C, Kurnaz S, Tuysuz E, Thaker NG, Giritlioglu D, Noel Meza JP.   +6 more
europepmc   +1 more source

DCAF13 Safeguards Hematopoietic Stem Cells via RRS1‐Regulated Ribosome Biogenesis

Advanced Science, EarlyView.
This study establishes DCAF13 as an essential regulator for hematopoietic stem cell (HSC) function. Its deletion in mice causes lethal pancytopenia and HSC depletion. Mechanistically, DCAF13 interacts with RRS1 and mediates its non‐degradative K27‐linked ubiquitination, thereby stabilizing RRS1 to maintain ribosome biogenesis and protein translation ...
Mengke Li, Yuxin Wu, Shuai Zhou, Peipei Tang, Jiaming Wei, Ling Liu, Zhenyi Wang, Deyang Shi, Shengnan Yuan, Qingyu Zhang, Shihui Wang, Qing Zhang, Huan Zhao, Rui Zhang, Yingying Wang, Shiwei Yang, Xiangli Chen, Xiaojing Shi, Guangzhi Liu, Yuwei Zhang, Jinming Li, Xu Dong Zhang, Rick F Thorne, Dongping Wei, Zumin Zhu, Song Chen   +25 more
wiley   +1 more source

LLM-supported collaborative ontology design for data and knowledge management platforms. [PDF]

Front Big Data
Kampars J, Mosans G, Jogi T, Roters F, Vajragupta N.   +4 more
europepmc   +1 more source

TEAD1 Enhances Exosome Secretion and Promotes Exosome‐Mediated Tissue Regeneration

Advanced Science, EarlyView.
TEAD1 functions as a crucial molecular switch regulating exosome secretion in various cell types. TEAD1 enhances exosome secretion by upregulating key proteins associated with exosome secretion, including RAB11, CD9, and SNAP23. This study reveals a novel role for TEAD1 in regulating exosome secretion and tissue regeneration, particularly in diabetic ...
Yan Pu, Yi Wan, Wenhao Shi, Bin Li, Haiyue Zhang, Jun Wu, Lingling Li, Wenjia Guo, Chen Ding, Wenjun Yang   +9 more
wiley   +1 more source

The Ontology of Adverse Events in 2025. [PDF]

Sci Data
Pan C, Yang Q, Zhang X, Luo S, He Y, Xie J.   +5 more
europepmc   +1 more source

Ontology-based cooperation of information systems : contributions to database-to-ontology mapping and XML-to-ontology mapping

, 2010
This thesis treats the area of ontology-based cooperation of information systems. We propose a global architecture called OWSCIS that is based on ontologies and web-services for the cooperation of distributed heterogeneous information systems. In this thesis, we focus on the problem of connecting the local information sources to the local ontologies ...
openaire   +1 more source

Discovery of H2 Receptor Antagonists as Colistin Enhancers by Targeting Acid Stress Response

Advanced Science, EarlyView.
This study identifies YqgB as a key target for restoring colistin susceptibility in mcr‐positive pathogens under acidic conditions by remodeling phospholipid composition and reducing LPS modification. Deep learning‐based screening reveals H2 receptor antagonists as novel colistin adjuvants. Further investigations indicate that ranitidine and famotidine
Jinju Cai, Mengping He, Jianya Luo, Shuang Zhou, Tengyue Zhang, Jianing Li, Zhiqiang Wang, Yuan Liu   +7 more
wiley   +1 more source

A data migration and integration approach for big data management using linked data. [PDF]

Sci Rep
Sattar H, Al-Khasawneh MA, Shafi UF, Hussain T, Saudagar AKJ, Ul Abideen SZ, Kamal MM, Jahfar Khan SB.   +7 more
europepmc   +1 more source