Results 221 to 230 of about 269,978 (302)

Large-scale mapping of environmental-genetic interactions illustrates the dynamic nature of cell-cycle and DNA repair regulation. [PDF]

Mol Cell
Herken BW, Wong GT, Mäkiniemi A, Lundberg E, Norman TM, Gilbert LA.   +5 more
europepmc   +1 more source

A Nanoparticle‐Integrated Complete Manufacturing Pipeline of Chemically Engineered Exosomes

Advanced Science, EarlyView.
We report a novel manufacture technology of chemically engineered exosomes. The four steps of manufacturing, i.e., biogenesis, loading, isolation, and storage, are integrated by the use of a nanoparticle. The manufacture technology incorporates three innovative components, i.e., a new nano‐bio effect, a new composite nanoparticle, and a new isolation ...
Xiaowei Wen, Zixing Xu, Zerun Hao, Yanming Chen, Kai Xie, Haofan Yin, Xueying Wang, Jie Min, Sihan Sun, Baiding Chen, Chengxiu Ling, Mingming Xu, Yizhao Chen, Gang Ruan   +13 more
wiley   +1 more source

The NIAID Discovery Portal: a unified search engine for infectious and immune-mediated disease datasets. [PDF]

mSystems
Tsueng G, Bullen E, Czech C, Welzel D, Collares L, Lin J, Rodolpho E, Qazi Z, Acosta N, Mayer LM, Venkatachari S, Mitrović Vučičević Z, Burman PN, Jain D, DiGiovanna J, Giovanni M, Lin A, Van Panhuis W, Hughes LD, Su AI, Wu C.   +20 more
europepmc   +1 more source

A Tac1‐Expressing Brainstem Pathway Underlies the Pathogenesis of Trigeminal Neuralgia

Advanced Science, EarlyView.
A critical TG‐Sp5CTac1‐PBNTac1 pathway drives trigeminal neuropathic pain (TNP). Tac1‐expressing parabrachial nucleus (PBNTac1) neurons exhibit heightened responses to innocuous stimuli in TNP, and chemogenetic inhibition of these neurons effectively prevents TNP development.
Liting Sun, Jia‐Jia Wang, Xiang‐Yu Li, Xin‐Yi Lin, Juan Li, Qiu‐Tong Yu, Zi‐Han Wang, Xue‐Ping Gao, Lei Jin, Wei‐Ke Li, Tian‐Lin Cheng, Juan Deng   +11 more
wiley   +1 more source

Semantic alignment of the German Human Genome-Phenome Archive metadata model in Europe's genomics field. [PDF]

Sci Data
Mauer K, Iyappan A, Parker S, Sürün B, Tremper G, Menges P, Kuchenbecker L, Kirli K, Schultze JL, Nahnsen S, Ulas T, GHGA Consortium.   +11 more
europepmc   +1 more source

A Testis‐Specific Aralkylamine N‐Acetyltransferase Regulates Dimorphic Sperm Function and Male Fertility in Moths

Advanced Science, EarlyView.
We identify a Lepidoptera‐conserved testis‐specific arylalkylamine N‐acetyltransferase (LTNAT) that governs male moth fertility via a novel mechanism. LTNAT loss disrupts eupyrene sperm mitochondrial derivatives and impairs apyrene sperm motility, offering a safe molecular target for innovative pesticides and genetic pest control.
Hao Sun, Peng‐Yi Huang, Zhi‐Ruo Zhang, Cong‐Fen Gao, Subba Reddy Palli, Shun‐Fan Wu   +5 more
wiley   +1 more source

Construction of Personal Health Knowledge Graphs for Clinical Data Harmonization in Breast Cancer

Liang W, Mierlo Rv, Bynens A, Celebi R, Erol E, Kılıç ÖD, de Zegher I, Serafimova K, Primov T, Boytcheva S, Kargl M, Maasik M, Wolfs CJ, Gomes AL, Dekker A, Kalendralis P.   +15 more
europepmc   +1 more source

PomBase in 2026: expanding knowledge, modeling connections. [PDF]

Genetics
Carme P, Rutherford K, Bähler J, Mata J, Wood V.   +4 more
europepmc   +1 more source

Single‐Cell Transcriptomics Reveals FLS2‐Dependent Hypoxia Signaling and ERF13‐Mediated Transcription During flg22‐Triggered Immunity

Advanced Science, EarlyView.
This study employs sc‐RNA sequencing, genetics, and phenotyping to systematically map the cell‐type‐specific immune responses triggered by flg22. It reveals FLS2‐dependent transcriptional reprogramming in epidermal and mesophyll cells, and uncovers crosstalk between immune and hypoxia signaling pathways.
Yaping Zhou, Aizhi Qin, Mengfan Li, Qianli Zhao, Luyao Kong, Lulu Yan, Chunyang Li, Hao Liu, Yinpeng Zhang, Jiani Long, Mengyu Liao, Mengmeng Zhou, Xiaoli Fan, Baozhen Wang, Wenxuan Kang, Shui Wang, Zhixin Liu, Xuwu Sun   +17 more
wiley   +1 more source

Simultaneous spatial transcriptomics and morphology profiling as tools to explore how microglia change with age. [PDF]

Nat Aging
Henze DE, Tsai AP, Wyss-Coray T, Quake SR.   +3 more
europepmc   +1 more source