Results 201 to 210 of about 38,633 (261)

First Generation Proteolysis Targeting Chimeras (PROTACs) for the Treatment of Progeria

Advanced Science, EarlyView.
We report the first PROTACs designed to degrade progerin, introducing a novel therapeutic approach for progeria. The best compound, UCM‐18142, significantly reduces progerin levels and improves key disease phenotypes in patient‐derived cells and in the LmnaG609G/G609G mouse model, paving the way for new treatment strategies targeting the root cause of ...
Jon Macicior‐Michelena, Marcelino Telechea, Daniel Fernández, Alba García‐Martín, Ángeles Canales, Silvia Ortega‐Gutiérrez   +5 more
wiley   +1 more source

Data Mining and Biochemical Profiling Reveal Novel Biomarker Candidates in Alzheimer's Disease. [PDF]

Int J Mol Sci
Vernone A, Stura I, Guiot C, D'Agata F, Silvagno F.   +4 more
europepmc   +1 more source

Ontology matching OM-2018

, 2018
Shvaiko, P., Euzenat, J., Jimenez-Ruiz, E., Cheatham, M., Hassanzadeh, O.   +4 more
openaire   +1 more source

The Age‐Dependent Resident Myonuclear Multi‐Omic Response to an Acute Skeletal Muscle Hypertrophic Stimulus in Mice

Advanced Science, EarlyView.
Resident myonuclei are the molecular “control centers” for large multinuclear muscle fibers. It is presumed that, with aging, these control centers become compromised and contribute to delayed or blunted muscle adaptive potential. This study is a detailed roadmap that exposes how young versus aged myonuclei respond to a hypertrophic loading stimulus ...
Pieter J. Koopmans, Ronald G. Jones III, Ana Regina Cabrera, Francielly Morena, Nicholas P. Greene, John J. McCarthy, Ahmed Ismaeel, Yuan Wen, Kevin A. Murach   +8 more
wiley   +1 more source

IMGT® at scale: FAIR, dynamic, and automated tools for immune locus analysis. [PDF]

Nucleic Acids Res
Sanou G, Zeitoun G, Manso T, Eidi M, Batool S, Kushwaha A, Grand F, Croze M, Vaillant A, Debbagh C, Abdollahi N, Georga M, Papadaki A, Sideri I, Samadova T, Jabado-Michaloud J, Folch G, Giudicelli V, Duroux P, Kossida S.   +19 more
europepmc   +1 more source

In Vivo CRISPR Screening Identifies the Glutamate Receptor GRIA2 as Promoting Peritoneal Metastasis of Gastric Cancer via Calcium‐Dependent β‐Catenin Activation

Advanced Science, EarlyView.
We identified GRIA2 as a critical driver of gastric cancer peritoneal metastasis through in vivo CRISPR screening. Mechanistically, GRIA2‐mediated calcium influx inhibits GSK3β and activates Wnt/β‐catenin signaling, driven by glutamate from cancer‐associated fibroblasts.
Jie Sun, Xu Yang, Wenchao Jiang, Chengbo Ji, Yingying Wu, Haoyu Sun, Xinyou Liu, Masami Yamamoto, Tetsuya Tsukamoto, Sachiyo Nomura, Junjie Zhao, Yuanyuan Ruan, Haojie Li, Xuefei Wang   +13 more
wiley   +1 more source

CMEO: a metadata-centric ontology for clinical studies exploration and harmonization assessment. [PDF]

BMC Med Inform Decis Mak
Gilani K, Wei W, Peters C, Verket M, Rocca HB, Nicolis E, Colombo M, Marx-Schütt K, Urovi V, Dumontier M.   +9 more
europepmc   +1 more source

Evaluation of Dexmedetomidine-Associated Bradycardia and Related Drug-Drug Interactions Using Electronic Health Record (EHR) and miRNA Target Analysis. [PDF]

Curr Issues Mol Biol
Zhu X, Kuppa SA, Morris R, Bui L, Liu X, Hill A, Cheng F.   +6 more
europepmc   +1 more source

Ontology development and use for cholangiocarcinoma risk factors and predictions: a term enrichment data analysis and machine learning classification. [PDF]

J Biomed Semantics
Pengput A, Diehl AD.
europepmc   +1 more source