Results 241 to 250 of about 1,139,414 (359)

A natural language processing approach to support biomedical data harmonization: Leveraging large language models. [PDF]

PLoS One
Li Z, Prabhu SP, Popp ZT, Jain SS, Balakundi V, Alvin Ang TF, Au R, Chen J.   +7 more
europepmc   +1 more source

POMap: An Effective Pairwise Ontology Matching System

, 2017
Amir Laadhar, Faïza Ghozzi, Imen Megdiche, Franck Ravat, Olivier Teste, Faı̈ez Gargouri   +5 more
openalex   +1 more source

Novel Evolutionarily Conserved Oncogene COA4 is Driven by KRAS Mutant and Promotes Cancer Metastasis Through Dual Mitochondrial Metabolism‐Dependent and ‐Independent Mechanisms

Advanced Science, EarlyView.
In KRAS‐mutant tumors, KRAS transcriptionally upregulates COA4 via the PI3K/AKT/E2F1 axis, promoting metastasis. Mechanistically, COA4 enhances tumor cell migration through dual pathways: within mitochondria, it boosts oxidative phosphorylation; in the cytoplasm, it binds and activates CDC42 to stimulate pseudopodia formation.
Xingzhao Ji, Weiying Zhang, Fuyuan Xue, Jiazhen Zeng, Qinghua Zhao, Xiaoming Sun, Jian Sun, Heng Zhou, Quanlin Xu, Guoyuan Ma, Shengnan Sun, Ying Wang, Qian Mu, Yi Liu, Qiang Wan   +14 more
wiley   +1 more source

Semantic approaches for query expansion: taxonomy, challenges, and future research directions. [PDF]

PeerJ Comput Sci
Allahim A, Cherif A, Imine A.
europepmc   +1 more source

BHLHE40 Cooperates with GATA2/3 to Control Human Syncytiotrophoblast Lineage Differentiation

Advanced Science, EarlyView.
BHLHE40 interacts directly with GATA2 and GATA3 and co‐occupies genomic loci critical for STB differentiation and function. BHLHE40 also affects GATA2/3 binding at enhancer and promoter regions. Moreover, BHLHE40 is potentially involved in genome‐wide remodeling of H3K4me3 and H3K27ac chromatin landscapes through GATA2/3 recruitment, activating ...
Lijin Peng, Weijie Zhao, Chunfang Xu, Yue Li, Jiani Guo, Taotao Zhou, Philip Chiu, Huimei Wu, Qingyu Wu, Yanxing Wei, Shaorong Gao, Meirong Du   +11 more
wiley   +1 more source

medicX-KG: a knowledge graph for pharmacists' drug information needs. [PDF]

J Biomed Semantics
Farrugia L, Azzopardi LM, Debattista J, Abela C.   +3 more
europepmc   +1 more source

Single‐Cell Dissection of the Biological Function and Molecular Features Underlying the Micropeptide LSMEM1 in Kidney

Advanced Science, EarlyView.
LSMEM1, an evolutionarily conserved micropeptide with extreme hydrophobicity (aliphatic index═113) and dynamic amphiphilicity (GRAVY═0.017), features a strong α‐helical transmembrane anchor (residues 64‐86). Single‐cell analysis reveals its critical role in renal lipid homeostasis.
Peimin Liu, Hong Zhang, Shanzhi Yang, Jiaoqing Li, Danfeng Wu, Haosen Xu, Huan Jiang, Yi Jing, Guoxiang Jin, Ruobing Liu, Ning Fan, Xiaoyan Bai   +11 more
wiley   +1 more source

VarGuideAtlas: a repository of variant interpretation guidelines. [PDF]

Database (Oxford)
Costa M, García S A, Pastor O.
europepmc   +1 more source

Linked data meets ontology matching: enhancing data linking through ontology alignments

, 2011
François Scharffe, Jérôme Euzenat
openalex   +1 more source

A Novel Therapeutic Strategy for Bone Marrow Failure: Niche Rejuvenation Using Costal Cartilage‐Derived Stem Cells

Advanced Science, EarlyView.
CDSCs exhibit the potential to differentiate into endothelial cells, vascular pericytes, and osteoblasts. These differentiated cells are capable of secreting additional pro‐hematopoietic cytokines. Furthermore, CDSCs can inhibit apoptosis and reduce DNA damage in injured hematopoietic stem and progenitor cells (HSPCs, including RHSCs and RHPCs), while ...
Rui Dong, Zhiguo Ling, Pengyuan Fan, Debao Li, Jinsong Wang, Wenjiong Shi, Rui Zuo, Runfeng Chen, Xuemin Sun, Lang Xiao, Yushi Ran, Shucheng Huang, Yi Tian, Chao Zhang, Yuzhang Wu, Bing Ni, Yi Zhang   +16 more
wiley   +1 more source