Results 281 to 290 of about 246,958 (342)

GPD1L‐Mediated Glycerophospholipid Metabolism Dysfunction in Women With Diminished Ovarian Reserve: Insights From Pseudotargeted Metabolomic Analysis of Follicular Fluid

Cell Proliferation, EarlyView.
Our study demonstrated the downregulation of GPD1L and its mediated glycerophospholipid metabolism dysfunction in patients with diminished ovarian reserve. Moreover, we verified that GPD1L knockdown leads to increased cell apoptosis and mitochondrial dysfunction of KGN cells, as well as impaired oocyte quality.
Jiaqi Wu, Xuehan Zhao, Ying Fang, Cong Wang, Yichang Tian, Wan Tu, Qiqian Wu, Long Yan, Xiaokui Yang   +8 more
wiley   +1 more source

Expression Profiling and Function Analysis Identified New Cumulus Cells-Expressed Genes and miRNAs Predictive of Oocyte Developmental Potential. [PDF]

Cells
Zhang M, Wang MM, Zhang FL, He N, Luo MJ, Gong S, Fu FY, Yuan HJ, Zhang J, Tan JH.   +9 more
europepmc   +1 more source

Production and Functional Verification of 8‐Gene (GGTA1, CMAH, β4GalNT2, hCD46, hCD55, hCD59, hTBM, hCD39)‐Edited Donor Pigs for Xenotransplantation

Cell Proliferation, EarlyView.
Schematic representation of generation of 8‐gene‐edited cloned pigs and their verification by pig to non‐human primate kidney xenotransplantation. ABSTRACT Gene‐edited (GE) pig‐to‐human xenotransplantation continues to make breakthroughs, but which kind of gene combination is suitable for organ‐specific transplantation remains unclear.
Jiaoxiang Wang, Kaixiang Xu, Tao Liu, Heng Zhao, Muhammad Ameen Jamal, Gen Chen, Xiaoying Huo, Chang Yang, Deling Jiao, Taiyun Wei, Hanfei Huang, Hongfang Zhao, Jianxiong Guo, Fengchong Wang, Xiong Zhang, Kai Liu, Siming Qu, Gang Wang, Hui Guo, Gang Chen, Hong‐Ye Zhao, Zhong Zeng, Kefeng Dou, Hong‐Jiang Wei   +23 more
wiley   +1 more source

Heat stress affects the functionality of the ovine cumulus-oocyte complex and subsequent in vitro embryo production. [PDF]

Sci Rep
Martín-Maestro A, Sánchez-Ajofrin I, Iniesta-Cuerda M, Medina-Chávez D, Maside C, Fernández-Santos MR, Garde J, Soler AJ.   +7 more
europepmc   +1 more source

Deciphering Sequence Determinants of Zygotic Genome Activation Genes: Insights From Machine Learning and the ZGAExplorer Platform

Cell Proliferation, EarlyView.
We compiled a comprehensive set of ZGA genes from mice, humans, pigs, bovines and goats, demonstrating the cross‐species conservation. An interpretable machine learning model, based on k‐mer core features, accurately predicted ZGA genes, revealing abundant and intricate six‐base sequence‐specific patterns and potential binding TFs.
Jixiang Xing, Siqi Yang, Yuchao Liang, Pengwei Hu, Bingjie Dai, Hanshuang Li, Yongqiang Xing, Yongchun Zuo   +7 more
wiley   +1 more source

Evaluation of Assisted Reproductive Technology Outcomes Using Crossover Administration of Two Recombinant Follicle-Stimulating Hormones in the Same Patients. [PDF]

Cureus
Kokeguchi S, Okamoto E, Mizusawa Y, Shibahara H, Yamagami K, Furuhashi K, Shiotani M.   +6 more
europepmc   +1 more source

Revitalising Aging Oocytes: Echinacoside Restores Mitochondrial Function and Cellular Homeostasis Through Targeting GJA1/SIRT1 Pathway

Cell Proliferation, EarlyView.
ECH protects senescent oocytes by stabilising the cytoskeleton, restoring mitochondrial function, reducing oxidative stress and maintaining cellular homeostasis, primarily through the GJA1/SIRT1 signalling pathway. ABSTRACT As maternal age increases, the decline in oocyte quality emerges as a critical factor contributing to reduced reproductive ...
Liuqing Yang, Xinle Lai, Fangxuan Lin, Nan Shi, Xinya Xu, Heng Wang, Xiaotian Li, Dan Shen, Haimo Qian, Xin Jin, Jiayi Chen, Zhongwei Huang, Xing Duan, Qin Zhang   +13 more
wiley   +1 more source

Integrated Multi-Omics Analysis Reveals Key Regulators of Bovine Oocyte Maturation. [PDF]

Int J Mol Sci
Kassim Y, Sheng H, Xu G, Jin H, Iqbal T, Elashry M, Zhang K.   +6 more
europepmc   +1 more source

Hypertranscription of rDNA Responsible for Nucleolar Remodelling is a Doorman for Acquiring Pluripotency

Cell Proliferation, EarlyView.
Active nucleoli have the capability to release perinuclear heterochromatin, which is a novel event of iPSC reprogramming. ABSTRACT Ribosome biogenesis occurs within the nucleolus, with the initial step being the transcription of ribosomal DNA (rDNA). Although rDNA transcription is limited in somatic cells, it is more active in stem cells. Nevertheless,
Yuchen Sun, Xinglin Hu, Xingwei Huang, Wenyao Zhou, Shubing Lan, Hui Zhang, Guangming Wu, Lei Lei   +7 more
wiley   +1 more source