Results 331 to 340 of about 415,920 (397)

Neonatal Outcomes Among Infants of Mothers With Advanced Maternal Age: A National Cohort Study

Acta Paediatrica, EarlyView.
ABSTRACT Aim Maternal age has increased steadily worldwide over the last few decades. This study aimed to investigate how different degrees of advanced maternal were associated with adverse neonatal outcomes. Methods A nationwide register‐based study was conducted using the Swedish Medical Birth Register.
S. Voss, A. Josefsson, C. Ekéus
wiley   +1 more source

Reproductive patterns and birth rates in acute leukaemia survivors: A Danish population‐based cohort study

British Journal of Haematology, EarlyView.
Treatment‐related infertility is of great concern to younger long‐term survivors of acute leukaemia (AL). The literature on fertility outcomes in adult long‐term AL survivors is limited, mainly focused on stem cell transplantation or childhood leukaemia, with little information on the use of assisted reproduction technology.
Nanna N. Nielsen, Jonas F. Jensen, Andreas Øvlisen, Ditte R. Zenas, Claudia Schöllkopf, Nina Toft, Andreas D. Ørskov, Dennis L. Hansen, Ingolf Mølle, Daniel T. Kristensen, Marianne T. Severinsen   +10 more
wiley   +1 more source

UBE2V1 governs aging induced protein aggregation and developmental defects in oocytes and embryos. [PDF]

Commun Biol
Li L, Liu Y, He X, Chen J, Guan X, Han L.   +5 more
europepmc   +1 more source

Pharmacological evaluation of non‐nucleotide purine derivatives as P2X7 antagonists for the treatment of neuroinflammation in traumatic brain injury

British Journal of Pharmacology, EarlyView.
Background and purpose Traumatic brain injury (TBI) is considered to be a leading cause of mortality and disability worldwide. After TBI, innate immunity is rapidly activated in response to damage‐associated molecular patterns, such as ATP release, recognised by P2X7 receptors.
Inés Valencia, Andrea Pastor‐Martínez, Céline Decouty‐Pérez, Ana Belen Lopez‐Rodriguez, María Álvarez‐Rubal, Eva Ramos, Francesco Calzaferri, Jorge Zamorano‐Fernández, Javier Giner‐García, Alexis J. Palpán‐Flores, Víctor Rodríguez‐Domínguez, Javier Rodríguez de Cía, Borja J. Hernández‐García, Alejandro Romero, Cristóbal de los Ríos, Javier Egea   +15 more
wiley   +1 more source

Investigating SMYD3 role during oocyte maturation in a 3D follicle-enclosed oocyte <i>in vitro</i> model in sheep. [PDF]

Front Cell Dev Biol
Camerano Spelta Rapini C, Peserico A, Di Berardino C, Capacchietti G, Rojo-Fleming C, Damian-Buda AI, Unalan I, Boccaccini AR, Grossi V, Mattioli M, Barboni B.   +10 more
europepmc   +1 more source

The fast‐dissociating D2 antagonist antipsychotic JNJ‐37822681 is a neuronal Kv7 channel opener: Potential repurposing for epilepsy treatment

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Pharmacological activation of neuronal M‐current mediated by Kv7 (Kv7.2–5) potassium channels is a validated mechanism for epilepsy treatment. However, since the market withdrawal of the prototype Kv7 activator retigabine, no Kv7 activator is clinically available for this condition.
Lidia Carotenuto, Oliver Keminer, Giusy Carleo, Andrea Zaliani, Antonio Leo, Rita Citraro, Giovambattista De Sarro, Nina Dirkx, Marcus Kaji, Sarah Weckhuysen, Jeanette Reinshagen, Vincenzo Barrese, Natascia Guida, Carmine Ostacolo, Francesco Miceli, Philip Gribbon, Maurizio Taglialatela   +16 more
wiley   +1 more source

A matrix-free 3D in vitro follicle culture system in mice exhibits enhanced oocyte meiotic and developmental competence compared to hydrogel encapsulation. [PDF]

Mol Hum Reprod
Zisiadi A, Billooye K, Anckaert E.
europepmc   +1 more source

Compartmentalisation in cAMP signalling: A phase separation perspective

British Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

Condensate-forming eIF4ET ensures adequate levels of meiotic proteins to support oocyte storage. [PDF]

Life Sci Alliance
Bhatia P, Tafur J, Amin R, Familiari NE, Yaguchi K, Tran VM, Bond A, Bukulmez O, Woodruff JB.   +8 more
europepmc   +1 more source

Beyond synapses: cytoplasmic connections in brain function and evolution

Biological Reviews, EarlyView.
ABSTRACT Following Ramón y Cajal's groundbreaking contributions to the identification of synapses, research in neuroscience predominantly focused on their pivotal role in neural communication (the neuron doctrine), overlooking an intriguing possibility suggested by Golgi of non‐synaptic interactions among neural cells.
Malalaniaina Rakotobe, Chiara Zurzolo
wiley   +1 more source