Results 101 to 110 of about 16,824,143 (312)
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Ralf Schimmer beantwortet Fragen über die Positionierung der Max Planck Gesellschaft zu Open Access und spricht auch über Motive und Zeitpunkt der Veröffentlichung der programmatischen Schrift „Disrupting the subscription journals' business model for the
Ralf Schimmer, Bruno Bauer
doaj +1 more source
Mit der Etablierung von Open Access als Standardmodell des wissenschaftlichen Publizierens verlagert sich der Fokus von Subskriptions- auf Publikationskosten. Die zuverlässige und vollständige Erfassung dieser Kosten stellt eine große Herausforderung für
Claudia Frick, Christian Kaier
doaj +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Science Tracking über Transformationsverträge und Wissenschaftsplattformen
Der Text untersucht einige Aspekte von Science Tracking, verstanden als die systematische und großflächige digitale Überwachung von Wissenschaft und Wissenschaftler:innen durch ehemalige Großverlage, die als Oligopol den Publikationsmarkt dominieren.
Yuliya Fadeeva
doaj +1 more source
Youth mental health is of paramount significance to society globally. Given early onset of mental disorders and the inadequate access to appropriate services, a meaningful service transformation, based on globally recognized principles, is necessary. The
A. Malla +23 more
semanticscholar +1 more source
Other title: Office of Children Services Transformation initial findings report [PDF]
"February 2020."; "Mike DeWine, Governor of Ohio; Jon Husted, Lt. Governor of Ohio."; "Ohio Governor's Children's Initiative, Children Services Transformation."; "Safe children. Stable homes.
Ohio. Children Services Transformation Advisory Council
core
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Das Diamond-Open-Access-Modell KOALA aus erwerbungsbibliothekarischer Sicht
Basierend auf einer großen Befragung werden die Perspektiven von in der Erwerbung tätigen Bibliothekar*innen auf konsortiale Open-Access-Finanzierungsangebote untersucht.
Julian Schenke +2 more
doaj +1 more source

