Results 21 to 30 of about 45,205 (207)

Etiopathogenesis of primary open-angle glaucoma [PDF]

Vestnik oftal'mologii, 2020
The article reviews literature covering the etiopathogenesis and risk factors for the development of primary open-angle glaucoma (POAG). Currently, this problem is one of the most complex and controversial in ophthalmology. The review considers the main theories: vascular, mechanical (retentional, hydromechanical), dystrophic (theory of primary ...
N V, Eliseeva, M I, Churnosov
openaire   +2 more sources

POLYMORPHISM OF EYE DRAINAGE SYSTEM CHANGES IN GLAUCOMA

Сибирский научный медицинский журнал, 2019
The study aim was to investigate structural peculiarities of sclera in different types of glaucoma, with an accent on changes of the eye drainage system. Materials and methods.
A. K. Lazareva, E. A. Tashlykova, S. V. Aydagulova, O. N. Kuleshova, V. V. Chernykh   +4 more
doaj   +1 more source

Mutations in the Myocilin Gene in Families With Primary Open-angle Glaucoma and Juvenile Open-angle Glaucoma [PDF]

Archives of Ophthalmology, 2003
To investigate the prevalence of myocilin (MYOC) mutations in Italian families with glaucoma and to determine the relationship of these mutations to primary open-angle glaucoma (POAG), juvenile open-angle glaucoma (JOAG), and pigmentary dispersion glaucoma.Twenty-six patients with POAG were selected based on a positive family history of glaucoma.
BRUTTINI M., LONGO I., FREZZOTTI P., CIAPPETTA R., RANDAZZO A., ORZALESI N., FUMAGALLI E., CAPOROSSI A., FREZZOTTI R., RENIERI A.   +9 more
openaire   +5 more sources

Large‐scale Whole‐Exome Sequencing Defines the Protein‐Coding Architecture of Retinal Structure, Visual Function, and Major Blinding Diseases

Advanced Science, EarlyView.
Large‐scale whole‐exome sequencing in 356,982 UK Biobank participants defines the protein‐coding architecture of retinal structure, visual function, and major blinding diseases. Pleiotropic genes, including CFI, C3, and RIOX1, bridge multiple retinal phenotypes, while experimental validation of FYB2 implicates RPE barrier dysfunction, providing ...
Jianqing Li, Yijun Ge, Jingxiao Du, Liu Yang, Bangsheng Wu, Chenyue Hang, Mengxi Shen, Yimin Mao, Ting Zhang, Qiyu Bo, Tianyuan Zhao, Yutian Jiao, Yazhi Wang, Shunxiang Gao, Jieqiong Chen, Junran Sun, Tong Li, Huixun Jia, Yang Dou, Wei Cheng, Xiaoling Wan, Jintai Yu, Xiaodong Sun, Bai Lu   +23 more
wiley   +1 more source

GWAS-by-subtraction reveals an IOP-independent component of primary open angle glaucoma

Nature Communications
The etiology of primary open angle glaucoma is constituted by both intraocular pressure-dependent and intraocular pressure-independent mechanisms.
Yu Huang, Denis Plotnikov, Huan Wang, Danli Shi, Cong Li, Xueli Zhang, Xiayin Zhang, Shulin Tang, Xianwen Shang, Yijun Hu, Honghua Yu, Hongyang Zhang, Jeremy A. Guggenheim, Mingguang He   +13 more
doaj   +1 more source

In Situ Photo‑Crosslinked Functional Bilayer Hydrogel Modulates Local Microenvironment and Remyelination After Optic Nerve Injury

Advanced Science, EarlyView.
A blue‐light‐crosslinked bilayer hydrogel was developed for local optic nerve repair. The adhesive GM‐Odex outer layer seals and anchors the lesion, while the non‐adhesive GM‐imid inner layer releases MPDA‐Cle without obstructing CSF flow. This system modulates oxidative and inflammatory microenvironments, supports oligodendrocyte differentiation and ...
Tonghe Pan, Yate Huang, Junhao Zhang, Shudong Tian, Zhixing Li, Xuanwen Li, Yanchen Zhang, Dongmei Wang, Sihao Ye, Ming Jin, Neng Ling, Wentao Yan, Kaihui Nan, Wencan Wu   +13 more
wiley   +1 more source

Optic Nerve Head Measurements Across Optical Coherence Tomography Platforms and Incidental Optic Nerve Head Drusen in Community Screenings

Eye &ENT Research, EarlyView.
ABSTRACT Background Automated vertical cup‐to‐disc ratio (VCDR) measurements are commonly used in optic nerve assessment, but measurements may vary across optical coherence tomography (OCT) platforms, particularly in eyes with atypical optic nerve anatomy such as optic nerve head drusen (ONHD).
Sedra T. Alabed, Aretha Zhu, Bernard C. Szirth, Albert S. Khouri   +3 more
wiley   +1 more source

The medical management of glaucoma

South African Family Practice, 2017
Glaucoma is one of the leading causes of blindness worldwide. The main characteristic features include optic disc cupping, visual field loss, and in most instances a raised intraocular pressure.
André Marais, Elzbieta Osuch
doaj   +1 more source

Artificial Intelligence in Ophthalmology: From Methodological Advances to Clinical Translation and Future Directions

Eye &ENT Research, EarlyView.
ABSTRACT Artificial intelligence (AI) is reshaping ophthalmology from task‐specific image analysis toward multimodal, longitudinal, and clinically integrated decision support. This narrative review summarizes the methodological evolution of ophthalmic AI, including traditional machine learning, task‐specific deep learning, self‐supervised learning ...
Yuxin Liu, Hanruo Liu
wiley   +1 more source

Artificial Intelligence in Optical Coherence Tomography‐Based Ophthalmic Imaging: From Automated Diagnosis to Personalized Disease Monitoring

Eye &ENT Research, EarlyView.
ABSTRACT Artificial intelligence (AI) is increasingly applied to optical coherence tomography (OCT) in ophthalmology, but evidence for automated diagnosis is stronger than evidence for longitudinal monitoring. This narrative review evaluates OCT‐based AI with emphasis on disease monitoring and progression, particularly in retinal disease and glaucoma ...
Stjepan Škudar
wiley   +1 more source