Results 81 to 90 of about 15,636 (294)
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
CES Transactions on Electrical Machines and SystemsCoal mine conveyor belt and other low-speed large torque system, the torque density and torque stability of the motor requirements are higher, permanent magnet / magnet reluctance hybrid rotor double stator synchronous motor (PM/MRHRDSSM) is just adapted
Yufeng Pang +3 more
doaj +1 more source
, 2007 A three-level space phasor generation scheme with common mode elimination and with reduced power device count is proposed for an open end winding induction motor in this paper. The open end winding induction motor is fed by the three-level inverters
Sivakumar, K +4 more
core
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
, 2009 A novel dodecagonal space vector structure for induction motor drive is presented in this paper. It consists of two dodecagons, with the radius of the outer one twice the inner one. Compared to existing dodecagonal space vector structures, to achieve the
Sivakumar, K +4 more
core
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Improved Duty Ratio-Based Direct Torque Control for Open-End Winding Induction Motor Drives
IEEE Open Journal of Industry ApplicationsThis article presents an improved duty-ratio-based direct torque control (Duty-DTC) scheme for open-end winding induction motor (OEWIM) drives. Unlike conventional DTC (CDTC), which applies a single voltage vector over the entire sampling interval, the ...
Kaif Ahmed Lodi +2 more
doaj +1 more source
Modulation and control strategies for multilevel five-phase open-end winding drives [PDF]
Industrial and automotive trends clearly demonstrate an increased interest in medium- and high-power variable speed drives. Despite constant progress in the technology, the semiconductor characteristics are still the bottleneck in drive designs, due to ...
Darijevic, M
core +1 more source
New 5-Phase Concentrated Winding Machine with Bi-Harmonic Rotor for Automotive Application [PDF]
, 2014 For a power range from 10 to 30 kW, 5-phase machines are well adapted to low-voltage (48V) supply thanks to their reduced current per phase. For three-phase machines but with higher voltages (>120V), machines with a number of slots per pole and per phase
B. Aslan +3 more
core +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source