Results 101 to 110 of about 156,017 (326)

Effectiveness and safety of baricitinib for juvenile idiopathic arthritis associated uveitis or chronic anterior antinuclear antibody positive uveitis

Arthritis Care &Research, Accepted Article.
Objectives Evaluate the efficacy and safety of baricitinib in paediatric patients with active JIA‐U or chronic anterior ANA‐positive uveitis, who had an inadequate response to MTX or bDMARDs. Methods JUVE‐BRIGHT was an open‐label, active‐controlled, Phase‐3 multicentre trial which utilized a novel design, including 1:1 randomization to an active ...
Athimalaipet V. Ramanan, Catherine M. Guly, Gabriele Simonini, Stuart Keller, Priyanka Sen, Thorsten Holzkaemper, Joana Araújo, Pierre Quartier   +7 more
wiley   +1 more source

Homeopathic treatment of children with attention deficit hyperactivity disorder: a randomised, double blind, placebo controlled crossover trial [PDF]

, 2018
An increasing number of parents turn to homeopathy for treatment of their hyperactive child. Two publications, a randomised, partially blinded trial and a clinical observation study, conclude that homeopathy has positive effects in patients with ...
Collenberg, Marco, Everts, Regula, Frei, Heiner, Fuhrer, Katharina, Hassink, Ralph, Hsu-Schmitz, Shu-Fang, Kaufmann, Franz, Steinlin, Maja, Thurneysen, André, von Ammon, Klaus, Walther, Daniel   +10 more
core  

Diffusion‐Weighted Imaging for the Evaluation of the Sacroiliac Joint in Pediatric Patients

Arthritis Care &Research, Accepted Article.
Background Maturational signal in the sacroiliac joint (SIJ) of skeletally immature youth is often misinterpreted as inflammation. Diagnostic tools that improve specificity are greatly needed. Apparent diffusion coefficient (ADC) values from diffusion‐weighted imaging (DWI), when used with standard imaging, may enhance diagnostic accuracy.
Michael L. Francavilla, Timothy G. Brandon, Dmitry Khrichenko, Rui Xiao, Nancy A. Chauvin, Asef Khwaja, Pamela F. Weiss   +6 more
wiley   +1 more source

Sarilumab in Polyarticular‐Course Juvenile Idiopathic Arthritis: Dose‐Finding and One‐Year Analysis of a Phase 2b, Open‐Label, Multicenter Study

Arthritis Care &Research, Accepted Article.
Objective This study assessed sarilumab in treating patients with polyarticular‐course juvenile idiopathic arthritis (pcJIA). Methods This phase 2b, open‐label study (NCT02776735) consisted of three sequential parts (each with a core‐treatment and extension‐phase). During part 1, three doses were assessed in two weight groups (Group A/B: ≥30–60 kg/≥10–<
Fabrizio De Benedetti, Inmaculada C. Penadés, Irina Nikishina, Ivan Foeldvari, Alberto J. Spindler, Anna Kozlova, Nadina Rubio‐Pérez, Pierre Quartier, Zbigniew Żuber, Raul Barria, Daniel Clemente, Gabriel V. Cornejo, Katherine Marzan, Nancy Liu, Christine Xu, Stephen DiMartino, Angeliki Giannelou, Fei Cao‐Ghoul, Bolanle Akinlade, Lydie Baret‐Cormel   +19 more
wiley   +1 more source

Enacting the mind/body connection: the role of self-induced placebo mechanisms

Humanities & Social Sciences Communications
Placebo effects are beneficial mind-body outcomes derived from beliefs or expectations, not explainable as the consequence of active medical treatments. These phenomena have long been considered a result of external manipulation, generally obtained with ...
Francesco Pagnini, Diletta Barbiani, Francesca Grosso, Cesare Cavalera, Eleonora Volpato, Giacomo Andrea Minazzi, Valentina Poletti, Giuseppe Riva, Deborah Phillips   +8 more
doaj   +1 more source

Update to the Vitamin C, Thiamine and Steroids in Sepsis (VICTAS) protocol: statistical analysis plan for a prospective, multicenter, double-blind, adaptive sample size, randomized, placebo-controlled, clinical trial. [PDF]

, 2019
BACKGROUND: Observational research suggests that combined therapy with Vitamin C, thiamine and hydrocortisone may reduce mortality in patients with septic shock.
Bernard, Gordon R., Busse, Laurence W., Ely, E. Wesley, Fowler, Alpha A., Gaieski, David F., Hager, David N., Hall, Alex, Hinson, Jeremiah S., Hooper, Michael H., Jackson, James C., Kelen, Gabor D., Levine, Mark, Lindsell, Christopher J., Martin, Greg S., McGlothlin, Anna, Nwosu, Samuel, Rice, Todd W., Rothman, Richard E., Sevransky, Jonathan E., Viele, Kert, Wright, David W.   +20 more
core   +1 more source

Beyond Inflammation: Why Understanding the Brain Matters in Inflammatory Arthritis

Arthritis Care &Research, EarlyView.
Persistent pain remains a major challenge in inflammatory arthritis, even when joint inflammation is well controlled. Pain and associated symptoms such as fatigue cannot be explained by peripheral inflammation alone but reflect altered central pain processing. These changes may arise through “top‐down” mechanisms, reflecting pre‐existing dysfunction in
Eoin M. Kelleher, Rosario Meouchi, Anushka Irani   +2 more
wiley   +1 more source

Open-label placebo treatment to improve relaxation training effects in healthy psychology students: a randomized controlled trial

Scientific Reports, 2021
Placebos, that are administered with deception, can reduce stress and increase relaxation. The present study investigated an open-label placebo (OLP) to improve the effects of Progressive Muscle Relaxation (PMR) training.
Anne Schienle, Isabella Unger
doaj   +1 more source

The effect of varying practitioner communication on patients' health status and treatment outcomes [PDF]

, 2011
This is the protocol for a review and there is no abstract. The objectives are as follows: To assess the effects of interventions in which healthcare practitioner communication in face-to-face consultations with patients is experimentally varied in ...
Ader, Beck, Benedetti, Benedetti, Benedetti, Bensing, Bensing, Bensing, Blasi, Cacioppo, Cameron, Clayton, Colloca, Crow, Deeks, DeVoe, Drummond, Ellington, Engel, Epstein, Fogarty, Goebel, Griffin, Gryll, Haes, Hall, Harrington, Herbison, Higgins, Kaptchuk, Klossika, Kong, Lieberman, McKinstry, Michie, Peters, Price, Robinson, Rose, Rosser, Roter, Roter, Schmid Mast, Shojania, Staud, Stewart, Stewart, Tang, Thomas, Vase, Vileikyte, Villemure, Yusuf   +52 more
core   +1 more source

Pharmacokinetics, Pharmacodynamics, and Safety of Subcutaneous Belimumab in Pediatric Patients with Systemic Lupus Erythematosus: A Multicenter, Open‐Label Trial

Arthritis Care &Research, Accepted Article.
Objective This study aimed to characterize the pharmacokinetics, pharmacodynamics, safety, and exploratory efficacy of subcutaneous belimumab in pediatric patients with active systemic lupus erythematosus (SLE) receiving standard therapy. Methods This single‐arm, multicenter, open‐label trial (GSK study 200908; NCT04179032) used three‐weight‐band ...
Hermine I. Brunner, Jordi Antón, Inmaculada Calvo‐Penadés, Richard Dimelow, Gerd Horneff, Sylvia Kamphuis, Rebecca Marino, Andre van Maurik, Kirsten Minden, Masaaki Mori, Josephine Ocran‐Appiah, Christel Wilkinson, Yuichi Yamasaki, Deepak Assudani, for the Pediatric Rheumatology Collaborative Study Group (PRCSG) and Paediatric Rheumatology International Trials Organisation (PRINTO) network investigators   +14 more
wiley   +1 more source