Results 131 to 140 of about 156,017 (326)

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

Advanced Science, EarlyView.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang, Jiangang Xu, Xinyu Zhou, Lu Che, Minghan Qiu, Yang Liu, Ming Gao, Zhen Yang   +7 more
wiley   +1 more source

The Democratic Biopolitics of PrEP [PDF]

, 2019
PrEP (Pre-Exposure Prophylaxis) is a relatively new drug-based HIV prevention technique and an important means to lower the HIV risk of gay men who are especially vulnerable to HIV.
Adam D Galinsky, Alain Giami, Amy L Hequembourg, Andrew D Forsyth, Barry D Adam, Beatriz Preciado, Bettina Schöne-Seifert, Carlos Novas, Catherine Mills, Christoph D Spinner, Christoph Menke, Cindy Patton, Daniel Grace, David M Halperin, David M Halperin, David M Halperin, Dawn K. Smith, Didier Fassin, Elizabeth F Closson, George Ayala, Giorgio Agamben, Giorgio Agamben, Heiner Meulemann, Hyman M Scott, Ingrid Young, Jaakko Ailio, Jaakko Ailio, Jaakko Ailio, Jae M Sevelius, Jared M Baeten, Jean-Michel Molina, Jeffrey Thomas Nealon, Jerome A Singh, Jessica E Haberer, Jessie L Juusola, Judith D Auerbach, Kane Race, Kane Race, Karen Schneider, Karsten Schubert, Kathleen R Page, Kimberly Koester, Latesha Elopre, Lauren V Wood, Mara Tognetti Bordogna, Marianne Pieper, Martin Holt, Martin Saar, Michael Hardt, Michael Hardt, Michel Foucault, Michel Foucault, Michel Foucault, Mingwang Shen, Mitchell Dean, Myron S Cohen, Myron S Cohen, Niels Doorn van, Nikolas Rose, Nikolas Rose, Nikolas Rose, Paul Rabinow, Paul Rabinow, Peter Langford, Robert M Grant, Roberto Esposito, Roberto Esposito, Roberto Esposito, Sarah K Calabrese, Sarit A. Golub, Shane P Collins, Sheena McCormack, Steven Epstein, Steven Epstein, Thea Cacchioni, Thomas Lemke, Thomas Lemke, Tim Dean, Tim Dean, Tim Dean, Tim Dean, Ulrich Bröckling, Ulrich Bröckling, Valentina Cambiano, Vinh-Kim Nguyen   +84 more
core   +5 more sources

Integrin β3 Orchestrates Hepatic Steatosis via a Novel CD36‐Dependent Lipid Uptake Complex

Advanced Science, EarlyView.
In MASH, ITGB3 recruits LYN and drives its ubiquitin‐proteasomal degradation via phosphorylation. This relieves DHHC5 inhibition, enabling ITGB3/DHHC5/CD36 complex assembly to enhance CD36 palmitoylation and fatty acid uptake, thereby exacerbating disease. Targeting ITGB3 blocks this pathogenic axis and ameliorates MASH.
Ying Zhang, Lei Dai, Zhongquan Cui, Ye Zhou, Wenyuan Dong, Hongcheng Jiang, Mengwen Wang, Xiaodan Zhong, Wei Dong, Zhang Yue, Thati Madhusudhan, Hongjie Wang, Xiong Zhong Ruan, Hesong Zeng   +13 more
wiley   +1 more source

Non-concealed placebo treatment for menopausal hot flushes: Study protocol of a randomized-controlled trial

Trials, 2019
Background Beneficial effects of placebos are high in double-blind hot flush trials. Studies in various conditions suggest that honestly prescribed placebos may elicit symptom improvement. Objective To determine whether open label placebo (OLP) treatment
Yiqi Pan, Ramona Meister, Bernd Löwe, Anne Winkelmann, Ted J. Kaptchuk, Kai J. Buhling, Yvonne Nestoriuc   +6 more
doaj   +1 more source

CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target

Advanced Science, EarlyView.
This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang, Huijie Bian, Zhi‐Nan Chen   +2 more
wiley   +1 more source

A trial like ALIC4E: why design a platform, response-adaptive, open, randomised controlled trial of antivirals for influenza-like illness?

ERJ Open Research, 2018
ALIC4E is the first publicly funded, multicountry, pragmatic study determining whether antivirals should be routinely prescribed for influenza-like illness in primary care.
Christopher C. Butler, Samuel Coenen, Benjamin R. Saville, Johanna Cook, Alike van der Velden, Jane Homes, Menno de Jong, Paul Little, Herman Goossens, Philippe Beutels, Margareta Ieven, Nick Francis, Pieter Moons, Emily Bongard, Theo Verheij   +14 more
doaj   +1 more source

Bevacizumab versus placebo in combination with paclitaxel and carboplatin as first-line treatment for recurrent or metastatic nasopharyngeal carcinoma: a multicentre, randomised, open-label, phase II trial

, 2021
Ting Zhou, Yunpeng Yang, S. Ma, Lizhu Lin, Ting Zhou, C. Zhang, Xiao Ding, Ruojun Wang, Guofei Feng, Y. Chen, Rui‐Hua Xu, Yuying Huang, L. Zhang   +12 more
openalex   +1 more source

Pain Response to Open Label Placebo in Induced Acute Pain in Healthy Adult Males

Anesthesiology, 2019
Background: Open label placebos with patient education are effective in reducing chronic pain, and recent studies on their effect on pain have established interest in this field.
T. Schneider, Julian Luethi, E. Mauermann, O. Bandschapp, W. Ruppen   +4 more
semanticscholar   +1 more source

Temperature and Farm Labor in Nigeria

Applied Economic Perspectives and Policy, EarlyView.
ABSTRACT We estimate the impact of temperature shocks on the composition of farm labor in rural Nigeria using a nationally representative household panel survey. Leveraging plausibly exogenous year‐to‐year variation in growing season temperatures, we find that warmer temperatures significantly alter farm labor composition, prompting a substantial shift
Andu Berha
wiley   +1 more source

Effects of Open- and Closed-Label Nocebo and Placebo Suggestions on Itch and Itch Expectations [PDF]

, 2019
Stefanie H. Meeuwis, Henriët van Middendorp, Antoinette I. M. van Laarhoven, Dieuwke S. Veldhuijzen, A.P.M. Lavrijsen, Andrea W.M. Evers   +5 more
openalex   +1 more source