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Open-label nondeceptive placebo analgesia is blocked by the opioid antagonist naloxone.
Pain, 2022Open-label placebos, or placebos without deception, have been found to induce analgesia, a challenging concept that need to be investigated in detail.
F. Benedetti +3 more
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Open-Label Placebo: Reflections on a Research Agenda
Perspectives in Biology and Medicine, 2018Open-label placebos (OLP)-placebo pills honestly prescribed-have challenged the notion that placebos require either deception or concealment to evoke salubrious benefits. This essay describes how the author arrived at the counter-intuitive OLP hypothesis, discusses evidence for OLP effectiveness, and examines mechanistic explanations for OLP.
T. Kaptchuk
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Enthusiastic claims for open-label placebo pills ignore the evidence.
Pain, 2020We have noticed a great deal of enthusiasm for open-label placebos lately. Open-label placebos refer to placebo interventions that are prescribed without either deception or concealment.
A. Amorim, G. Machado, C. Maher
semanticscholar +3 more sources
Effects of placebos without deception compared with no treatment: A systematic review and meta‐analysis [PDF]
Journal of Evidence-Based Medicine, 2017 Aim Our aim was to address the clinical efficacy of open-label placebos compared with no treatment by systematic review, and meta-analysis where possible.
James E G Charlesworth +2 more
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Open-Label Placebos Improve Symptoms in Allergic Rhinitis: A Randomized Controlled Trial
Psychotherapy and Psychosomatics, 2016M. Schaefer, Rebecca Harke, C. Denke
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Journal of Integrative and Complementary Medicine, 2022
Objective: An open-label placebo (OLP) is a placebo treatment in which the patient is aware that the treatment is a placebo. OLPs are considered effective for reducing pain, and previous studies have shown a stronger placebo effect for placebo acupuncture than for placebo pills.
Seoyoung Lee +4 more
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Objective: An open-label placebo (OLP) is a placebo treatment in which the patient is aware that the treatment is a placebo. OLPs are considered effective for reducing pain, and previous studies have shown a stronger placebo effect for placebo acupuncture than for placebo pills.
Seoyoung Lee +4 more
openaire +2 more sources
Why psychotherapy is an open-label placebo and open-label placebos are psychotherapy
2023Abstract In recent years, placebos have undergone a rapid development from methodological chaff to therapeutic wheat. Hereby, the role of placebos as a deceptive control in clinical trials, as well as negative denomination for anything murky, changed to an innovative promise, an effective as well as ethical treatment.
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Evidence-Based Practice, 2022
Placebo effects have traditionally involved concealment or deception. However, recent evidence suggests that placebo effects can also be elicited when prescribed transparently as “open-label placebos” (OLPs), and that the pairing of an unconditioned ...
E. Close, Kaitlyn M. Greer, Brock Mills
semanticscholar +1 more source
Placebo effects have traditionally involved concealment or deception. However, recent evidence suggests that placebo effects can also be elicited when prescribed transparently as “open-label placebos” (OLPs), and that the pairing of an unconditioned ...
E. Close, Kaitlyn M. Greer, Brock Mills
semanticscholar +1 more source
Open-label placebo reduces fatigue in cancer survivors: a randomized trial
Supportive Care in Cancer, 2018Cancer-related fatigue (CRF) is a common and challenging late effect for many cancer survivors. Clinical trials demonstrate robust placebo effects on CRF in blinded trials. Recently, open-label placebo (OLP) has been shown to improve a variety of symptoms in other populations.
Eric S. Zhou +5 more
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A Fictionalist Account of Open-Label Placebo
The Journal of Medicine and Philosophy: A Forum for Bioethics and Philosophy of MedicineAbstract The placebo effect is now generally defined widely as an individual’s response to the psychosocial context of a clinical treatment, as distinct from the treatment’s characteristic physiological effects. Some researchers, however, argue that such a wide definition leads to confusion and misleading implications.
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