Results 51 to 60 of about 31,862 (304)

MEOX1 Coordinates Autocrine‐Paracrine Programs via SPHK1/S1P to Promote Lymph Node Metastasis in Ovarian Cancer

Advanced Science, EarlyView.
In ovarian cancer, MEOX1 activates the SPHK1/S1P pathway to promote both tumor progression and tumor–stroma crosstalk. MEOX1‐dependent signaling drives CAF activation, enhances VEGF‐C expression, and stimulates lymphangiogenesis, ultimately facilitating lymph node metastasis.
Jiajia Li, Xiuling Zhi, Qianhan Lin, Yating Sun, Yihua Sun, Zulimire Abudousalamu, Mengyang Xue, Chang Zheng, Xiaotian Li, Liangqing Yao, Mo Chen   +10 more
wiley   +1 more source

Research on the intelligent capability maturity and evolution logic of open-pit coal mines

Gong-kuang zidonghua
Existing studies on the construction of intelligent open-pit coal mines have primarily focused on areas such as overall planning, basic architecture, and the evaluation of the completeness of construction content. However, there has been limited research
WANG Zhongxin, TIAN Fengliang, SUN Xin, GUO Xiaosong, HUANG Junting, WANG Lei, ZHANG Zhongwen, ZHAO Guangzhi, SONG Bo, ZENG Xiangyu   +9 more
doaj   +1 more source

Open pit uranium mine Zee-3

, 2022
Date scanned: 2002-7-16.Figure 8 Open pit uranium mine Zee-3. Outlined area "B" of figure 5.Held in the Russell L. and Lyn Wood Mining History Archive, Arthur Lakes Library, Colorado School of Mines.Donor: United States Bureau of Mines.An image of the ...

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Sustainable Materials Design With Multi‐Modal Artificial Intelligence

Advanced Science, EarlyView.
Critical mineral scarcity, high embodied carbon, and persistent pollution from materials processing intensify the need for sustainable materials design. This review frames the problem as multi‐objective optimization under heterogeneous, high‐dimensional evidence and highlights multi‐modal AI as an enabling pathway.
Tianyi Xu, Tianshuo Wei, Yan Ge, Bo Peng, Yue Li, Maolin Wang, Peng Wen, Chao Yang, Ye Wei   +8 more
wiley   +1 more source

Research on the overall framework and key technologies of intelligent open-pit mines

Gong-kuang zidonghua, 2021
Combined with the characteristics of open-pit mines in China, the definition of intelligent open-pit mines is given. This paper introduces the overall network architecture, business architecture and collaborative process of the intelligent open-pit mine.
FU Ensan1, LIU Guangwei2, ZHAO Hao3, QU Yeming4, DI Shuai1, JIANG Lin1   +5 more
doaj   +1 more source

Transposase‐Assisted Donor Tethering Boosts Large‐Fragment HDR in Plants

Advanced Science, EarlyView.
A transposase‐assisted donor tethering strategy is developed to enhance homology‐directed repair in plants. By recruiting donor DNA to double‐strand breaks and synergizing with repair pathway reprogramming and transcription‐coupled donor design, this system markedly improves large‐fragment targeted insertion efficiency, providing a robust platform for ...
Sha Wei, Kai Zhang, Shuke Deng, Jinjie Chen, Xiaomei Huang, Jingfei Guo, Yuqing Wu, Yingjie Guo, Zhen Liang   +8 more
wiley   +1 more source

Study on mechanical property degradation characteristics and damage mechanism of red sandstone under wetting-drying cycles

KSCE Journal of Civil Engineering
The damage evolution laws and failure characteristics of rocks subjected to wetting-drying cycles are critical for the stability control of rock mass engineering.
Yujing Jiang, Junxiao Han, Changsheng Wang, Jianrong Liu, Hengjie Luan, Sunhao Zhang, Jiale Wei   +6 more
doaj   +1 more source

Optimum ramp design in open pit mines

Computers & Operations Research, 2020
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Juan L. Yarmuch, Marcus Brazil, J. Hyam Rubinstein, Doreen A. Thomas   +3 more
openaire   +2 more sources

Alice Mine, view of west end of pit

, 2022
#3 - Evergreen Mines Company, Alice Mine. West end of Alice Mine showing ore body, cap rock, glacial drift and surrounding countryside. Eveleth, Minnesota. - October 1941.Date scanned: 2002-6-12.Held in the Russell L. and Lyn Wood Mining History Archive,

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ABHD17C‐Mediated S‐Depalmitoylation of BCL6B Enhances CD24 Transcription to Resist Macrophage Phagocytosis in Pancreatic Cancer

Advanced Science, EarlyView.
ABHD17C‐mediated depalmitoylation of BCL6B at Cys442 blocks its nuclear import and triggers ubiquitin‐dependent degradation, attenuating transcriptional repression of the anti‐phagocytic signal CD24. This mechanism enables pancreatic cancer cells to evade macrophage phagocytosis and fosters an immunosuppressive microenvironment.
Yalu Zhang, Di Cui, Fanzheng Meng, Xu Zhu, Liang Zhu, Liang Wu, Haifeng Hu, Jizhou Wang, Hanhui Yao, Lianxin Liu   +9 more
wiley   +1 more source