Results 221 to 230 of about 119,952 (305)

Risk model of long-term production scheduling in Open Pit Gold Mining [PDF]

, 2005
Halatchev, Rossen A., Lever, Paul J. A.
core  

Investigating transthyretin variants H88R and I107V in amyloid priming: From destabilization to complete dissociation

The FEBS Journal, EarlyView.
Investigated mutations in transthyretin (TTR) disrupt the F87‐centered hydrophobic core that stabilizes its tetrameric structure. The mild I107V mutation weakens inter‐chain packing, while H88R fully abolishes tetramer formation, yielding a monomeric, aggregation‐prone form. Structural, biophysical, and computational analyses reveal that both mutations
István L. Bódy, Zsolt Fazekas, Nóra Wágner, Anna J. Kiss‐Szemán, Veronika Harmat, Zoltán Pozsonyi, Dóra K. Menyhárd, András Perczel   +7 more
wiley   +1 more source

The green value chain model of mining company based on zero carbon emissions. [PDF]

Sci Rep
Fan C, Li G, Chen M, Hou J, Wei Q, Wang P, Guo G.   +6 more
europepmc   +1 more source

"A pick in one hand and a spade in the other". To what extent was life in a Carmarthenshire mining area different from one in Glamorgan between 1880 and 1914? [PDF]

, 2018
Evans, Sian
core  

Degradomics for large‐scale mechanistic insights on proteases and proteolysis in human health

The FEBS Journal, EarlyView.
Proteolysis has an important role in human disease but remains relatively unexplored. Degradomics, the uncovering of proteolysis in tissues, cells, and proteins, uses mass spectrometry‐based terminomics to identify protein termini occurring therein (forward degradomics) and to define the actions of proteases (reverse degradomics).
Daniel R. Martin, Sumit Bhutada, Suneel S. Apte   +2 more
wiley   +1 more source

Delineating homogeneous zones for rock joint wall mechanical properties in open-pit mine slope based on a multi-indicator stacked generalization model. [PDF]

Sci Rep
Yu X, Zheng A, Ye J, Qin J, An P, Wang R.   +5 more
europepmc   +1 more source

Tyrosine residues at the substrate binding site in human NQO1 homodimer: Protein conformational dynamics and optimization of substrate binding geometry

The FEBS Journal, EarlyView.
Human NAD(P)H:quinone oxidoreductase 1 is a homodimeric flavoenzyme crucial for redox metabolism and linked to significant health issues. Point mutations at Tyr126 and Tyr128 demonstrate their essential roles in optimizing substrate binding geometry for catalysis, as well as in half‐site reactivity and conformational dynamics during the enzyme's ...
Maribel Rivero, Juan Luis Pacheco‐Garcia, Pavla Vankova, Dmitry Loginov, Isabel Quereda‐Moraleda, Jose Manuel Martin‐Garcia, Petr Man, Angel Luis Pey, Milagros Medina   +8 more
wiley   +1 more source

UAV coal-rock recognition and 3D coal seam model dynamic correction technology in open-pit mine. [PDF]

Sci Rep
Yuan J, Liu G, Chai S, Guo W, Huang Y.
europepmc   +1 more source

Development of CCMb: A Low‐Mg Calcite Reference Material for In Situ Measurement of δ18O, δ13C and Selected Trace Elements

Geostandards and Geoanalytical Research, EarlyView.
Key Points Low‐Mg calcite RM developed for in situ microanalysis applications in palaeoclimatology (δ18O, δ13C; Mg, Sr m/m). New data for calcite CRM IAEA‐603 (δ18O, δ13C by SIMS and GS‐IRMS; Mg m/m). No detectable IMF effect of Mg on SIMS δ18O determinations for mass fractions < 3650 μg g‐1.
Andreas T. Hertwig, Maciej G. Śliwiński, Irene Cantarero, Richard A. Stern, Carles Fàbrega, Jakub T. Śliwiński, Thomas Ludwig, František Majs, William Nachlas, John H. Fournelle, Xavier Llovet, Rachelle B. Turnier, David Parcerisa, Anna Travé   +13 more
wiley   +1 more source

Enhancing sustainability in mining by reducing hauling energy consumption through optimization of distance and slope with semi-mobile in-pit crushers and conveyors. [PDF]

Sci Rep
Nikbin R, Bagherpour R, Purhamadani E, Taherinia A.   +3 more
europepmc   +1 more source