Results 291 to 300 of about 18,672,321 (342)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

DoE-It-Yourself (DoEIY): An Open-Access Web Application for Democratizing Experimental Design in Chemical and Materials Research. [PDF]

Small Methods
Mac Fhionnlaoich N, Yang Y, Qi R, Galvanin F, Guldin S.   +4 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

RadRepro CBCT: An Open-Access CBCT Phantom Dataset for Improved Standardization and Reproducibility of Radiomics Research. [PDF]

Sci Data
Hatamikia S, Steiner E, Muniya EJ, Elmirad S, Borji A, Kronreif G, Birkfellner W, Buschmann M.   +7 more
europepmc   +1 more source

<i>K</i> _OC-WebPredictor: An Open-Access Tool for Prediction and Insights into Soil Sorption. [PDF]

ACS Omega
Li L, Amin SA, Kar S, Piotto S.
europepmc   +1 more source

Promoting awareness of open access publishing in speech-language therapy and audiology: Lessons from multilingual language assessment research. [PDF]

S Afr J Commun Disord
Bornman J, Bortz M, Edwards A, Louw B, Van der Linde J.   +4 more
europepmc   +1 more source

VIGMA: An Open-Access Framework for Visual Gait and Motion Analytics. [PDF]

IEEE Trans Vis Comput Graph
Omar KS, Wang S, Kungumaraju R, Bhatt T, Miranda F.   +4 more
europepmc   +1 more source