Results 31 to 40 of about 8,971,076 (260)

Evaluating Treatment Choice in Patients with Moderate to Severe Psoriasis in the United States: Results from a US Patient Survey

Dermatology and Therapy
Introduction While multiple treatments are available for moderate to severe psoriasis, patient preferences are rarely systematically studied. This study aims to identify factors associated with choice of a new once-daily oral psoriasis treatment, elicit ...
April W. Armstrong, Sayeli Jayade, Sanika Rege, Namita Joshi, Vardhaman Patel, Samaneh Kalirai, Daniel Wolin, Kimberly Boyle, Dipen Patel, Lauren Seigel   +9 more
doaj   +1 more source

Mechanisms and kinetic assays of aminoacyl‐tRNA synthetases

FEBS Letters, EarlyView.
Accurate protein synthesis is crucial for life. The key players are aminoacyl‐tRNA synthetases (AARSs), which read the genetic code by pairing cognate amino acids and tRNAs. AARSs establish high amino acid selectivity by employing physicochemical limits in molecular recognition.
Igor Zivkovic, Morana Dulic, Ita Gruic‐Sovulj   +2 more
wiley   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Engaging Indigenous partners in health service transformation: a framework for sustained engagement built on trust

Research Involvement and Engagement
Health research and service delivery often fail to incorporate Indigenous worldviews and local community protocols, as well as historic experiences and knowledge of harmful research practices leaving Indigenous individuals wary of participating in ...
Carolyn M. Melro, Meghan Gilfoyle, Clifford Ballantyne, Lacey Augustine, Gregory Brass, Norma Rabbitskin, Daphne Hutt-Macleod, Srividya N. Iyer, Christopher J. Mushquash   +8 more
doaj   +1 more source

Improved Antibacterial Properties of Fermented and Enzymatically Hydrolyzed Bee Pollen and Its Combined Effect with Antibiotics

Pharmaceuticals
Background/Objectives: A variety of phytochemicals from different plants are collected by bees into bee pollen granules. This research focused on evaluating the effects of lactic acid fermentation and enzymatic hydrolysis on the antibacterial activity of
Vaida Damulienė, Vilma Kaškonienė, Paulius Kaškonas, Rūta Mickienė, Audrius Maruška   +4 more
doaj   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

FEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield, Torsten Kleffmann, David J. Saul, Sigurd M. Wilbanks   +3 more
wiley   +1 more source

Constructing experimental indicators for Open Access documents [PDF]

, 2006
The ongoing paradigm change in the scholarly publication system ('science is turning to e-science') makes it necessary to construct alternative evaluation criteria/metrics which appropriately take into account the unique characteristics of electronic ...
Mayr, Philipp
core   +2 more sources

The weakest link – workflows in open access agreements: the experience of the Vienna University Library and recommendations for future negotiations

Insights: The UKSG Journal, 2018
In recent years open access (OA) publishing agreements have left a lasting impact on several aspects of the research life cycle, and on the manner in which institutions work with publishers and researchers to support the transition to OA.
Rita Pinhasi, Guido Blechl, Brigitte Kromp, Bernhard Schubert   +3 more
doaj   +1 more source

Analysis of the Leaves and Cones of Lithuanian Hops (Humulus lupulus L.) Varieties by Chromatographic and Spectrophotometric Methods

Molecules, 2022
This work involves a comprehensive chemical composition analysis of leaf and cone samples of Lithuanian hop varieties. This study aimed to determine the chemometric properties of the leaves and cones of five Lithuanian hop varieties.
Žydrūnas Stanius, Mantas Dūdėnas, Vilma Kaškonienė, Mantas Stankevičius, Elżbieta Skrzydlewska, Tomas Drevinskas, Ona Ragažinskienė, Kęstutis Obelevičius, Audrius Maruška   +8 more
doaj   +1 more source