Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Open Practices in Phytolith Research: A Community Survey
The open research movement has gained momentum in the last decade and no academic can ignore the necessity to make research more open, as it improves reliability, sustainability and reusability of data.
Javier Ruiz-Pérez +5 more
doaj +1 more source
A machine learning framework for discovery and enrichment of metagenomics metadata from open access publications. [PDF]
Nassar M +6 more
europepmc +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
The UK Research Councils (RCUK) introduced an open access pol- icy, and accompanying funding for Article Processing Charges (APCs), in April 2013. This article describes University College London (UCL)’s experience of managing its institutional, RCUK ...
Sharp, C
core
Graphical integrity issues in open access publications: Detection and patterns of proportional ink violations. [PDF]
Zhuang H, Huang TY, Acuna DE.
europepmc +1 more source
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
Open access journals and institutional repositories: practical need and present trends in India
Discusses the trends in open access publishing in India. Study is based on data collected from directories of open access journals and institutional repositories.
Devib, Maya +3 more
core
Scientific globalism during a global crisis: research collaboration and open access publications on COVID-19. [PDF]
Lee JJ, Haupt JP.
europepmc +1 more source
Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez +2 more
wiley +1 more source

