Results 81 to 90 of about 2,750,739 (393)
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
Collaborative Open Access Publishing
, 2021 Presentation of the publication 'The Open Science Guide of Guides' for OAT21 Open Science has become an indispensable part of modern science. There are several definitions of "openness" in relation to different aspects of science - the Open Definition sets out principles as follows “Open means anyone can freely access, use, modify, and share for any ...
Blümel, Ina +2 more
openaire +2 more sources
Ligand recognition by 14‐3‐3 proteins requires negative charges but not necessarily phosphorylation
FEBS Letters, Volume 599, Issue 6, Page 838-847, March 2025.Interactions of 14‐3‐3 proteins with their binding partners are attributed to phosphorylation of the binding partners. In this work, we show that at least one negative charge is required for the peptides to bind 14‐3‐3ε, although phosphorylation is not necessary, and that two negative charges are preferable for high affinity binding.
Seraphine Kamayirese +2 more
wiley +1 more source
Human colon organoid differentiation from induced pluripotent stem cells using an improved method
FEBS Letters, Volume 599, Issue 6, Page 912-924, March 2025.We compared established protocols to differentiate induced pluripotent stem cells into colon organoids and found that activation of bone morphogenetic protein 2 signaling induced gene expression of colon‐specific markers. Adenovirus‐mediated transduction of the transcription factors HOXD13 or SATB2 further enhanced colonic gene expression, suggesting ...
I‐Ting Lee +4 more
wiley +1 more source
Information Services & Use, 2003 In order to do justice to the collective and universal nature of science, the free exchange of research results is nothing less than imperative. This can only mean free and open access to these results. Before the internet, the physical limitations of print made universal open access a practical impossibility. But now that the internet is proving to be
openaire +2 more sources
ELPUB 2019 23d International Conference on Electronic Publishing, 2019 Academic publishing is changing. The drive towards open access publishing, which is being powered in the UK by funding bodies (SHERPA Juliet), the requirements of REFs 2021 (UKRI) and 2027 (Hill 2018), and Europe-wide movements such as the recently ...
L. Barnes, Rupert Gatti
semanticscholar +1 more source
FEBS Letters, Volume 599, Issue 7, Page 1055-1074, April 2025.Hermansky‐Pudlak syndrome type 1 (HPS‐1) is a rare, autosomal recessive disorder with poorly understood renal involvement. Urinary extracellular vesicle (uEV) proteomics and a novel Hps1 mouse model reveal mitochondrial abnormalities and lipid accumulation in HPS‐1 kidney proximal tubule cells. Serum ApoA1 correlates with kidney function in our patient
Dawn M. Maynard +7 more
wiley +1 more source
Academic publishing and open access [PDF]
, 2013 With the spread of the internet and new opportunities for publishing academic works digitally at virtually no costs, the traditional copyright model has recently been put under critical review which is for at least two reasons: First and foremost, a vast increase in subscription prices for academic journals has forced (university) libraries to ...
Frank Mueller-Langer, Marc Scheufen
openaire +2 more sources
General cost analysis for scholarly communication in Germany : results of the "Houghton Report" for Germany [PDF]
, 2012 Management Summary: Conducted within the project “Economic Implications of New Models for Information Supply for Science and Research in Germany”, the Houghton Report for Germany provides a general cost and benefit analysis for scientific communication ...
Bernius, Steffen +4 more
core
FEBS Letters, Volume 599, Issue 7, Page 1075-1085, April 2025.We describe a novel set of Epac‐based FRET‐FLIM biosensors with improved fully cytosolic distribution, achieved without compromising the state‐of‐the‐art performance of our original designs, for detecting cAMP dynamics in real time in live cells with high precision and reliability.
Giulia Zanetti +2 more
wiley +1 more source