Results 121 to 130 of about 96,836 (298)

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Ecological Resilience Through Green Infrastructure: Analyzing the Role of Private Green Open Spaces in Tropical Megacities

Green open space is decreasing along with urban development. Development in urban areas has an impact on reducing green land which is important for urban resilience.
Inavonna, Inavonna, Wijayanto, Punto, Tjiook, Wiwi, Winandari, Maria Immaculata Ririk, Aziiz, Akhlish Diinal, Ischak, Mohammad, Saskia, Cut Sannas, Fatmawati, Teungku Nelly   +7 more
core   +2 more sources

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Analyzing urban green space inequalities in Isparta, Turkey

TeMA: Journal of Land Use, Mobility and Environment
Cities defined by population size, heterogeneity, and dynamic change face historical and contemporary inequalities. The United Development Goals underline the urgency of addressing urban inequality, which has been exacerbated by the COVID-19 pandemic ...
Atila GÜL, Gizem Dinç, Çağla Aydemir
doaj   +1 more source

Green open spaces: collective practices

, 2014
56 σ.Η παρούσα εργασία επιχειρεί να αποτυπώσει μία συνολική εικόνα των χώρων που έχουν προκύψει τα τελευταία χρόνια ως ‘έργο συλλογικό’ και ‘από τα κάτω προς τα πάνω’ με έμφαση στους χώρους πρασίνου, τόσο μικρού όσο και μεγαλύτερου μεγέθους, οι οποίοι ...
Gkika, Aliki, Γκίκα, Αλίκη
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

STUDY OF THE COMFORT LEVEL OF GREEN OPEN SPACE IN GEDONG TATAAN SUB-DISTRICT

Jurnal Belantara
The conversion of land in urban areas, especially Green Open Space (GOS), into development land causes green land to decrease, coupled with the increasing volume of vehicles.
Kurnia Albarkati Nia, Christine Wulandari, Hari Kaskoyo, Samsul Bakri, Indra Gumay Febryano   +4 more
doaj   +1 more source

Adequacy and Accessibility Analysis of Open and Green Spaces in Osmaniye Center

, 2021
The scarcity of open and green spaces, which should be an integral part of the urban fabric and urban planning, is not a big metropolitan city problem in Turkey anymore but is a challenging problem of even medium and small-sized cities, one of which is ...
Savran, Sezen, Çolakkadıoğlu, Deniz, Kahveci, Barış   +2 more
core  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source