Results 91 to 100 of about 101,208 (262)
Role Of Green Open Space In Performance Improvement Of Malang City Center
This study is a continuation of previous research [5],[6],[7], on the hierarchy of the Green Open Space’s role of the city based on its 9 classifications (Green Line, City Park, Urban forest, Garden Tomb, Sports Park, Rotonde, Monument Park, Playground ...
subhan ramdlani, Lisa Dwi Wulandari
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Abstract Urban growth dynamics have resulted an increase in population and rapid conversion of green open space (GOS) into built-up areas. Despite the minimum standard provision has been stated 30% on spatial regulation Law No 26/2007, Bekasi City Government has been struggling to preserve their remaining valuable green open spaces. This
H Ajrina, I Kustiwan
openaire +1 more source
Structure‐forward targeting of claudins with synthetic binders
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Discerning protein pools by selective staining with self‐labeling tags
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Urban green areas are often seen in highly developed countries as urban green lungs because of their ability to mediate between man and nature. However, it is not the case in developing countries, where the means of subsistence are considered pivotal ...
Josiah Nwabueze Obiefuna +3 more
doaj +1 more source
Urban Greening Through Participatory Governance: Managing Green Open Spaces in Bekasi, Indonesia [PDF]
Rapid urbanisation poses a major challenge for cities in Indonesia in maintaining green open spaces as part of sustainable urban planning. The city of Bekasi is a case in point, where despite an increase of green open spaces, this achievement has not yet
Safitri Nur Dewi, Kholid Anwar
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source

