Results 161 to 170 of about 15,612,381 (255)

Application of Virtual Twin PBPK Models in Individuals with Obesity via CYP3A4 Phenotyping Using Endogenous Biomarker Data

open access: yesClinical Pharmacology &Therapeutics, Volume 120, Issue 3, Page 762-773, September 2026.
Plasma 4β‐hydroxycholesterol (4β‐OHC) normalized for the levels of its parent cholesterol (4β‐OHC/C) is an endogenous biomarker for hepatic CYP3A4. This study evaluated CYP3A4 activity longitudinally in individuals while their obesity status was changing. 4β‐OHC/C was measured pre‐surgery (n = 54) and 2 years after Roux‐en‐Y gastric bypass (n = 30) and
Nihan Izat   +6 more
wiley   +1 more source

Laparoscopic Versus Open Cholecystectomy in Older Adults: A Systematic Review and Meta-Analysis of Postoperative Outcomes (2000-2026). [PDF]

open access: yesCureus
Hassan AMI   +11 more
europepmc   +1 more source

Deferred Cytoreductive Nephrectomy With Partial Hepatectomy for Giant Renal Cell Carcinoma of the Right Kidney With Extensive Hepatic Invasion: A Case Report in the Era of Systemic Immune Checkpoint Inhibitors and Tyrosine Kinase Inhibitors

open access: yesIJU Case Reports, Volume 9, Issue 5, September 2026.
ABSTRACT Introduction Deferred cytoreductive nephrectomy may improve the prognosis of patients with metastatic renal cell carcinoma (RCC). However, reports of combined hepatic resection for RCC with liver invasion are limited, and treatment strategies remain insufficiently established.
Yuki Hiroshi   +8 more
wiley   +1 more source

A Case of Open Cholecystectomy for Acute Cholecystitis in a Patient with an Implanted Left Ventricular Assist Device on the Waiting List for a Deceased Donor Heart Transplantation. [PDF]

open access: yesSurg Case Rep
Migita K   +13 more
europepmc   +1 more source

Bile acid metabolism and signaling in human and animal health: A One Health perspective

open access: yesiMetaOmics, Volume 3, Issue 3, September 2026.
Bile acids maintain host homeostasis through enterohepatic circulation, microbial transformation, and bile acid receptor signaling, thereby regulating glucose and lipid metabolism, intestinal barrier integrity, and immunity. These effects support human disease intervention and health‐oriented animal production, reducing drug dependence and residue ...
Lei Li   +7 more
wiley   +1 more source

Past, Present, and Future of Telerobotic Surgery in Urology: From Technological Breakthroughs to Global Adoption

open access: yesiNew Medicine, Volume 2, Issue 3, September 2026.
The Development and Future of Remote Robots in Urology. ABSTRACT Ever since the “Lindbergh Operation” in 2001, the field of remote robotic surgery has transformed from theoretical study toward practical clinical integration on a global scale. Considering the millimeter‐level precision that is required in the field of urological oncology, remote ...
Cheng Yang   +6 more
wiley   +1 more source

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