Results 111 to 120 of about 458,301 (316)
Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA
Molecular Oncology, EarlyView.Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson +2 more
wiley +1 more source
Open Cluster Dynamics under the Influence of Outflow–Ambient Interactions
The Astrophysical JournalStars with outflows impinging on ambient gas experience accelerations due to the gravitational feedback from the interaction morphology between the outflow and the ambient gas.
Muxin Liu +3 more
doaj +1 more source
Assessment of the impact of a new sequential approach to antimicrobial use in young febrile children in the emergency department (DIAFEVERCHILD): a French prospective multicentric controlled, open, cluster-randomised, parallel-group study protocol. [PDF]
BMJ Open, 2020 Hubert G +7 more
europepmc +1 more source
Search for Low–Instability Strip Variables in the Young Open Cluster NGC 2516 [PDF]
, 1998 F. M. Zerbi +3 more
openalex +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
The Astrophysical Journal Supplement Series, 1985 Rotational velocities and spectral types have been determined for Be stars in 12 open clusters in both the northern and the southern sky, and color-magnitude or H-R diagrams constructed for each from available photometric data. The location of the Be stars in the color-magnitude diagrams shows again that Be stars may exist in various evolutionary ...
openaire +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Extra-Tidal Members and Dynamics of the Open Cluster NGC 6705
Applied SciencesIn this study, we utilized Gaia-DR3 astrometric data combined with the density-based spatial clustering of applications with noise (DBSCAN) algorithm to thoroughly investigate the dynamics and extra-tidal members of the open cluster NGC 6705.
Chen Zhou, Xinhua Gao
doaj +1 more source
Galactic Structure Toward the Open Clusters NGC 188 and NGC 3680 [PDF]
, 1996 R. A. Méndez, W. F. van Altena
openalex +1 more source