Results 271 to 280 of about 5,726,855 (364)

Impact of proactively inviting people with advanced cancer to talk about the end of life: a randomised clinical trial protocol. [PDF]

BMJ Open
Julià-Torras J, García-Salanova A, Monforte-Royo C, Jimeno Ariztia M, Balaguer A, Crespo I.   +5 more
europepmc   +1 more source

CD9‐association with PIP2 areas is regulated by a CD9 salt bridge

FEBS Open Bio, EarlyView.
The tetraspanin CD9 has an intracellular salt bridge. If CD9 opens, open‐CD9 moves from PIP2‐rich areas to regions populated by its interaction partner EWI‐2. Hence, the state of the salt bridge regulates the distribution of CD9 and by this CD9‐EWI‐2 complex formation.
Yahya Homsi, Sara C. Konopka, Thorsten Lang   +2 more
wiley   +1 more source

Implementation and effectiveness of a nurse-enabled, shared-care follow-up model for early breast cancer survivors (The IBIS-Survivorship Study): protocol for a stepped-wedge cluster randomised trial. [PDF]

BMJ Open
Chan RJ, Crawford-Williams F, Koczwara B, Mann GB, Eakin E, Turner J, Krishnasamy M, Collins LG, Skerman H, Hemming K, Hart NH, Emery J, Crowe B, Patford K, Mahony J, Kristunas C, Blanchard G, Healey L, Sanmugarajah J, Liang R, Craft P, Shorthouse A, McCaffery R, Azer M, Yates P.   +24 more
europepmc   +1 more source

Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial

The Lancet, 2017
M. Lean, W. Leslie, A. Barnes, Naomi Brosnahan, G. Thom, Louise McCombie, C. Peters, S. Zhyzhneuskaya, A. Al-Mrabeh, K. Hollingsworth, Angela M Rodrigues, L. Rehackova, A. Adamson, F. Sniehotta, J. Mathers, H. Ross, Yvonne McIlvenna, R. Stefanetti, M. Trenell, P. Welsh, S. Kean, I. Ford, A. McConnachie, N. Sattar, Roy Taylor   +24 more
semanticscholar   +1 more source

Characterization of WAC interactions with R2TP and TTT chaperone complexes linking glucose and glutamine availability to mTORC1 activity

FEBS Open Bio, EarlyView.
TTT and R2TP chaperone complexes are required for the assembly and activation of mTORC1. WAC directly interacts with components of TTT, R2TP, and mTORC1, and these interactions are affected by the availability of glucose and glutamine, correlating with changes in mTORC1 activity.
Sofía Cabezudo, Natalia Cuervo, Carmen García‐Martín, Andrés López‐Perrote, Clara Reglero, Adrián Maqueda‐Real, Ana González‐Corpas, Marina Serna, Diego Megías, Alejo Efeyan, Solip Park, Oscar Llorca   +11 more
wiley   +1 more source

Effects of a digital tool implementing the German S3 clinical practice guideline for multimorbidity in primary care (gp-multitool.de): study protocol for a cluster-randomised controlled trial. [PDF]

BMJ Open
Schäfer I, Menzel A, Lezius S, Krause L, Zapf A, Lühmann D, Scherer M, Paucke V, Nothacker J.   +8 more
europepmc   +1 more source

Ro 31‐8220 suppresses bladder cancer progression via enhancing autophagy in vitro and in vivo

FEBS Open Bio, EarlyView.
The pan‐protein kinase C inhibitor Ro‐31‐8220 demonstrates potent anti‐bladder cancer effects both in vitro and in vivo by suppressing migration/invasion, inducing apoptosis and crucially activating autophagy, where blocking autophagy with chloroquine reduces its cell‐killing efficacy, suggesting its promise as a novel therapeutic candidate requiring ...
Shengjun Fu, Yan Tao, Shan Wu, Yuwen Gong, Youli Zhao, Shaomin Niu, Hui Cheng, You Mu, Na Xu, Ying Wang, Jianzhong Lu, Shanhui Liu, Lanlan Li   +12 more
wiley   +1 more source

The cochaperone BAG3 promotes the stabilization of p53 under heat stress conditions

FEBS Open Bio, EarlyView.
Under heat stress, BAG3 translocates to the nucleus and forms a complex with Hsp70 and p53, thereby promoting p53 stabilization and enhancing its transcriptional activity. These findings suggest that BAG3 functions as a cochaperone that supports p53‐mediated stress responses in cooperation with Hsp70.
Ngoc Nguyen Thi Minh, Esther Lee, Soo‐A Kim   +2 more
wiley   +1 more source

Au₁₄₇(SPh)₃₀(PPh₃)₁₂: A Geometrically Closed, but Electronically Open Triple-Shell Icosahedral Gold Cluster and its Geometrically Open Counterpart. [PDF]

Angew Chem Int Ed Engl
Strienz M, Poddelskii A, Moll BK, Schrenk C, Thomas PS, Clayborne AZ, Schnepf A.   +6 more
europepmc   +1 more source

Berkeley 20: an unusual old open cluster

, 1994
Donn MacMinn, Randy L. Phelps, K. A. Janes, Eileen D. Friel   +3 more
openalex   +1 more source