Results 281 to 290 of about 5,900,834 (385)

Evaluation of synaptotagmin‐1 action models by all‐atom molecular dynamics simulations

open access: yesFEBS Open Bio, EarlyView.
We used molecular dynamics simulations to test models proposing that synaptotagmin‐1 facilitates membrane fusion by perturbing lipid bilayers, inducing membrane curvature and/or bridging membranes. The simulations show that synaptotagmin‐1 C2‐domains placed near the site of fusion hinder the ability of SNARE complexes to bring the membranes together ...
Josep Rizo   +2 more
wiley   +1 more source

Deep learning-based tennis match type clustering. [PDF]

open access: yesBMC Sports Sci Med Rehabil
Yun HJ, Jang N, Jeon M.
europepmc   +1 more source

The Contact Binary H235 in the Open Cluster NGC 752 [PDF]

open access: bronze, 1992
E. F. Milone   +5 more
openalex   +1 more source

Pharmacological effects of osimertinib on a chicken chorioallantoic membrane xenograft model with the EGFR exon‐19‐deleted advanced NSCLC mutation

open access: yesFEBS Open Bio, EarlyView.
Osimertinib reduces angiogenesis and PDL1 expression in in ovo tumors, transforming them into ‘cold tumors’ with lower immune activity. Anatomopathological and transcriptomic analyses highlight its therapeutic impact on tumor biology. This study underscores osimertinib's potential to reshape the tumor microenvironment and provides insights into its ...
David Barthélémy   +14 more
wiley   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

open access: yesFEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi   +2 more
wiley   +1 more source

A multiwavelength study of star formation in the very young open cluster NGC 6530 [PDF]

open access: bronze, 1997
M. E. van den Ancker   +5 more
openalex   +1 more source

Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial

open access: yesThe Lancet, 2017
M. Lean   +24 more
semanticscholar   +1 more source

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