Results 21 to 30 of about 407,861 (266)

Elucidation of interface interactions between a dehydratase domain and an acyl carrier protein in cremimycin polyketide synthase

open access: yesFEBS Letters, EarlyView.
In modular polyketide synthases, the dehydratase (DH) domain catalyzes the dehydration reaction of the β‐hydroxyacyl unit attached to the cognate acyl carrier protein (ACP) domain. However, it is unclear how DH interacts with ACP during the reaction. In this study, we identified DH–ACP interface residues, providing the first detailed insights into DH ...
Kaede Kotagiri   +8 more
wiley   +1 more source

Seismic constraints on open clusters [PDF]

open access: yesAstronomy & Astrophysics, 2005
We derive knowledge on the global and structural parameters of low-mass stars using asteroseismology and taking advantage of the stellar collective behavior within open clusters. We build stellar models and compute the seismic signal expected from main sequence objects in the 0.8-1.6 Msun range.
Piau, Laurent   +2 more
openaire   +3 more sources

Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases

open access: yesFEBS Letters, EarlyView.
The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher   +6 more
wiley   +1 more source

NGC 2180: A disrupting open cluster? [PDF]

open access: yesAstronomy & Astrophysics, 2004
9 pages, 8 ...
Charles Jose Bonatto   +2 more
openaire   +2 more sources

Insertion of the FeB cofactor in cNORs lacking metal inserting chaperones

open access: yesFEBS Letters, EarlyView.
Nitric oxide reductase is an enzyme found in the bacterial denitrification pathway. The NOR active site contains a non‐heme iron, often, but not always inserted with the assistance of chaperones. Here, we study the insertion of FeB in the subfamily of cNORs lacking chaperones and found a putative channel, conserved in the family, perhaps enabling the ...
Sofia Appelgren, Pia Ädelroth
wiley   +1 more source

NGC 6994: an open cluster which is not an open cluster

open access: yes, 2000
We report on CCD photometry in the Johnson B,V and I passbands for 146 stars in a 9' \times 9' region around the southern aggregate NGC 6994 (C 2056-128), which appears in the Lynga (1987) catalogue of open star clusters. We argue that this object is not really an open cluster, but simply a random enhancement of four bright stars above the background ...
openaire   +3 more sources

The orbits of open clusters in the Galaxy [PDF]

open access: yesMonthly Notices of the Royal Astronomical Society, 2009
We present and analyze kinematics and orbits for a sample of 488 open clusters in the Galaxy. The velocity ellipsoid for our present sample is derived as ($ _{U}$, $ _{V}$, $ _{W})$=$(28.7$, 15.8, 11.0) km s$^{-1}$ which represents a young thin disc population. We also confirm that the velocity dispersions increase with the age of cluster subsample.
Jun Ma, Zhenyu Wu, Xu Zhou, Cuihua Du
openaire   +4 more sources

Taurine promotes glucagon‐like peptide‐1 secretion in enteroendocrine L cells

open access: yesFEBS Letters, EarlyView.
Taurine, a sulfur‐containing amino acid, is likely taken up by enteroendocrine L cells via the taurine transporter. This process increases the levels of cytosolic ATP. The increase in intracellular Ca2+ concentrations and glucagon‐like peptide‐1 secretion through membrane depolarization is caused by the closure of ATP‐sensitive potassium channels ...
Yuri Osuga   +6 more
wiley   +1 more source

The multiple roles of the NlpC_P60 peptidase family in mycobacteria – an underexplored target for antimicrobial drug discovery

open access: yesFEBS Letters, EarlyView.
The NlpC_P60 superfamily of peptidases is recognised by its key role in bacterial cell wall homeostasis. Recently, studies have also described the involvement of NlpC_P60‐like enzymes in bacterial competitive mechanisms and pathogenesis across several lineages.
Catharina dos Santos Silva   +1 more
wiley   +1 more source

The Fundamental Plane of Open Clusters [PDF]

open access: yesThe Astrophysical Journal Letters, 2018
Abstract We utilize the data from the Apache Point Observatory Galactic Evolution Experiment-2 in the fourteenth data release of the Sloan Digital Sky Survey to calculate the line-of-sight velocity dispersion σ 1D of a sample of old open clusters (aged older than 100 Myr) selected from the Milky Way open cluster catalog
Xiaoying Pang, Shiyin Shen, Zhengyi Shao
openaire   +3 more sources

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