Results 81 to 90 of about 443,609 (315)

Basic Kinematics of the Galactic Disk from Open Cluster Data

Open Astronomy, 2016
The kinematic parameters of the Galactic disk are redetermined based on open-cluster data. It is shown that the Bottlinger-Oort model of pure circular rotation can be confidently used to describe the observed motions of disk objects at least out to ...
Loktin A. V., Popova M. E.
doaj   +1 more source

Mechanistic basis for inhibition of the extended‐spectrum β‐lactamase GES‐1 by enmetazobactam and tazobactam

FEBS Letters, EarlyView.
Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer, Philip Hinchliffe, Marko Hanževački, Christopher R. Bethel, Catherine L. Tooke, Marc W. Van der Kamp, Krisztina M. Papp‐Wallace, Robert A. Bonomo, Stuart Shapiro, Adrian J. Mulholland, James Spencer   +10 more
wiley   +1 more source

Vilnius Multicolor CCD Photometry of the Open Cluster NGC 752

Open Astronomy, 2011
We have performed multicolor CCD observations of the central area of NGC 752 to search for faint, low-mass members of this open cluster. Four 12’ x 12’ fields were taken on the 1.8 m Vatican Advanced Technology Telescope (Mt.
Bartašiūtė S., Janusz R., Boyle R. P., Philip A. G. Davis   +3 more
doaj   +1 more source

C9orf72 ALS‐causing mutations lead to mislocalization and aggregation of nucleoporin Nup107 into stress granules

FEBS Letters, EarlyView.
Mutations in the C9orf72 gene represent the most common genetic cause of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease. Using patient‐derived neurons and C. elegans models, we find that the nucleoporin Nup107 is dysregulated in C9orf72‐associated ALS. Conversely, reducing Nup107 levels mitigates disease‐related changes.
Saygın Bilican, Yara Nabawi, William Hongyu Zhang, Dunja Petrovic, Markus Wehrmann, Sara Muñoz‐García, Seda Koyuncu, David Vilchez   +7 more
wiley   +1 more source

β,β-Isomer of Open-Wells–Dawson Polyoxometalate Containing a Tetra-Iron(III) Hydroxide Cluster: [{Fe4(H2O)(OH)5}(β,β-Si2W18O66)]9−

Inorganics, 2016
The β,β-isomer of open-Wells–Dawson polyoxometalate (POM) containing a tetra-iron(III) cluster, K9[{Fe4(H2O)(OH)5}(β,β-Si2W18O66)]·17H2O (potassium salt of β,β-Fe4-open), was synthesized by reacting Na9H[A-β-SiW9O34]·23H2O with FeCl3·6H2O at pH 3, and ...
Satoshi Matsunaga, Eriko Miyamae, Yusuke Inoue, Kenji Nomiya   +3 more
doaj   +1 more source

Open clusters in AurOB2

, 2016
We study the area around the HII region Sh 2-234, including the young open cluster Stock 8, to investigate the extent and definition of the association Aur OB2 and the possible role of triggering in massive cluster formation. We obtained Str mgren and J,H,Ks photometry for Stock 8 and Str mgren photometry for two other cluster candidates in the area,
Marco, A., Negueruela, I.
openaire   +2 more sources

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source

Tidal tails of open clusters

Astronomy & Astrophysics
Context. Open clusters that emerged from the star-forming regions as gravitationally bound structures are subjected to star evaporation, ejection, and tidal forces throughout the rest of their lives. Consequently, they form tidal tails that can stretch kiloparsecs along the cluster’s orbit. Aims.
openaire   +2 more sources

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

THE PECULIARITIES IN O-TYPE GALAXY CLUSTERS

Odessa Astronomical Publications, 2017
We present the results of analysis of 2D distribution of galaxies in galaxy cluster fields. The Catalogue of Galaxy Clusters and Groups PF (Panko & Flin) was used as input observational data set.
E. A. Panko, S. I. Emelyanov
doaj   +1 more source