Results 111 to 120 of about 4,555,706 (361)
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Research on the Controlling Parameters of Creep-Thermal Fatigue Crack
Advances in Mechanical Engineering, 2013 The opening process of creep-thermal fatigue crack (CTFC) is studied by finite element method, considering the bilinear kinematic hardening and creep characteristic of the material.
Ming Yan, Xiang-jun Zhu, Shi-jie Wang
doaj +1 more source
Annular cracks in thin films of nanoparticle suspensions drying on a fiber
, 2013 We report an experimental study of the crack pattern formed during the drying of a colloidal suspension. A horizontal fiber, which provides a one dimensional, boundary-free substrate, is coated by a film of micronic thickness.
Boulogne, François +2 more
core +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
A fatigue crack initiation model incorporating discrete dislocation plasticity and surface roughness [PDF]
, 2007 Although a thorough understanding of fatigue crack initiation is lacking, experiments have shown that the evolution of distinct dislocation distributions and surface roughness are key ingredients.
Brinckmann, Steffen +1 more
core +4 more sources
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece +18 more
wiley +1 more source
Sensors, 2018 An exponential increase in large-scale infrastructure facilitates the development of wireless passive sensors for permanent installation and in-service health monitoring.
Jun Zhang +3 more
doaj +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Crack Open a Bottle of General Lee – A Second Course
, 2015 Welcome back, fellow historical diners. Last time, you joined me in comparing a fine selection of Union generals to food. Today, we’ll be examining some of their southern counterparts. Let’s dig in! Robert E.
Nadeau, Ryan M.
core