Results 131 to 140 of about 4,555,706 (361)
Closure of fatigue cracks at high strains [PDF]
Experiments were conducted on smooth specimens to study the closure behavior of short cracks at high cyclic strains under completely reversed cycling. Testing procedures and methodology, and closure measurement techniques, are described in detail.
Dowling, N. E., Iyyer, N. S.
core +1 more source
Early Stages of Fatigue Damage of Steels for Fusion Energetics [PDF]
, 2012 Hlavním cílem této práce bylo vysvětlit únavové chování ocelí ODS Eurofer, 14Cr ODS feritické oceli vyráběné v CEA (Commissariat a l’énergie atomique, Saclay, France) a 14Cr ODS feritické oceli vyráběné v EPFL (École Polytechnique Fédérale de Laussane ...
Kuběna, Ivo
core
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Curved crack paths are predicted by elastic-charges
Communications MaterialsPredicting crack trajectories in brittle solids remains an open challenge due to their non-local nature and the way they modify the surrounding medium. Here, we develop a framework for analytically predicting crack paths, analogous to predicting particle
Oran Szachter +4 more
doaj +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Investigation of Lateral Stress Relief on theStability of PHI = 0 DEG Slopes Using Laboratory, Fracture Mechanics, and Finite Element Method Approaches [PDF]
, 2011 Total stress analyses of purely cohesive cut slopes utilize the undrained shear strength for slope stability analyses. These slopes can have an in-situ lateral earth pressure that is greater than the vertical pressure.
Kutschke, Walter
core
Crack fronts and damage in glass at the nanometer scale
, 2003 We have studied the low speed fracture regime for different glassy materials with variable but controlled length scales of heterogeneity in a carefully mastered surrounding atmosphere.
Bouchaud E +12 more
core +1 more source