Results 41 to 50 of about 36,663 (266)
Cracking Open the Black Box [PDF]
Proceedings of the 2019 Workshop on Network Meets AI & ML - NetAI'19, 2019 Machine learning (ML) solutions to challenging networking problems, while promising, are hard to interpret; the uncertainty about how they would behave in untested scenarios has hindered adoption. Using a case study of an ML-based video rate adaptation model, we show that carefully applying interpretability tools and systematically exploring the model ...
Arnaud Dethise +2 more
openaire +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Fatigue crack growth analysis on square prismatic with embedded cracks under tension loading
Journal of Mechanical Engineering and Sciences, 2017 One of the most important issues yet to be overcome by engineers is the integrity and reliability of engineering structures. This is to ensure the safety of the engineering structure is at the greatest since the catastrophic failures usually occur due ...
M.S. Shaari +5 more
doaj +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Experimental identification of cracked rotor system parameters from the forward and backward whirl responses [PDF]
Archive of Mechanical Engineering, 2019 In the present work, an experimental investigation of a transverse fatigue crack has been carried out. A mathematical modelling of cracked rotor system along with the measured vibration is used to find crack parameters that not only detect the fault but ...
C. Shravankumar, Rajiv Tiwari
doaj +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Advances in Materials Science and Engineering, 2016 Based on the small time scale method, the influence of grain boundary on the fatigue crack growth of 7050-T7451 has been investigated. The interaction between fatigue crack and grain boundary was investigated by in situ SEM testing.
Weihan Wang +4 more
doaj +1 more source
Scientific Data, 2023 Monitoring of structures’ condition plays a fundamental role in providing safety for users and extending the structures’ lifespan. The monitoring is conducted through on-site inspections by engineers thus this process is time-consuming, labor-intensive ...
Karolina Tomaszkiewicz, Tomasz Owerko
doaj +1 more source