Results 201 to 210 of about 4,429,139 (309)

Open access, open data

sociorel, 2016
openaire   +2 more sources

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

RxTrends: An R-based Shiny Application for Visualising Open Data on Prescribed Medications in Ireland. [PDF]

HRB Open Res
Hassan Ali A, Flood M, Kirke C, Mattsson M, Walsh ME, Wallace E, Corrigan D, Fahey T, Boland F, Moriarty F.   +9 more
europepmc   +1 more source

Field data for the Vegetation Mapping Inventory Project of Stones River National Battlefield - Open Format Data Package

Inventory and Monitoring Division
openalex   +1 more source

The Impact of Venous Thromboembolism on Upper Tract Urothelial Carcinomas Undergoing Open or Minimally Invasive Radical Nephroureterectomy in the USA: Perioperative Outcomes and Health Care Costs from Insurance Claims Data [PDF]

Anas Tresh, Francesco Del Giudice, Shufeng Li, Satvir Basran, Federico Belladelli, Ettore De Berardinis, Vincenzo Asero, Matteo Ferro, Octavian Sabin Tătaru, Gian Maria Busetto, Ugo Giovanni Falagario, Riccardo Autorino, Felice Crocetto, Biagio Barone, Benjamin Pradère, Marco Moschini, Andrea Mari, Wojciech Krajewski, Łukasz Nowak, Bartosz Małkiewicz, Tomasz Szydełko, Simone Crivellaro, Abhay Rané, Ben Challacombe, Rajesh Nair, Benjamin I. Chung   +25 more
openalex   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

MDRepo-an open data warehouse for community-contributed molecular dynamics simulations of proteins. [PDF]

Nucleic Acids Res
Roy A, Ward E, Choi I, Cosi M, Edgin T, Hughes TS, Islam MS, Khan AM, Kolekar A, Rayl M, Robinson I, Sarando P, Skidmore E, Swetnam TL, Wall M, Xu Z, Yung ML, Merchant N, Wheeler TJ.   +18 more
europepmc   +1 more source

Review report on extended abstract titled "Open Data and Researcher Assessment in the Social Sciences and Humanities (SSH): Addressing Challenges and Building Tailored Support"

Peroni, Silvio, Vergoulis, Thanasis
openalex   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

Modelling the high-voltage grid using open data for Europe and beyond. [PDF]

Sci Data
Xiong B, Fioriti D, Neumann F, Riepin I, Brown T.   +4 more
europepmc   +1 more source