Results 231 to 240 of about 37,426,579 (266)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Modelling the high-voltage grid using open data for Europe and beyond. [PDF]

Sci Data
Xiong B, Fioriti D, Neumann F, Riepin I, Brown T.   +4 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Bariatric surgery in Poland in 2017-2022: retrospective analysis of public health system open data. [PDF]

J Diabetes Metab Disord
Kamiński M, Wyleżoł M, Kręgielska-Narożna M, Bogdański P.   +3 more
europepmc   +1 more source

Exploring environmental risk in soils: Leveraging open data for non-sampling assessment? [PDF]

Heliyon
Aparisi-Navarro S, Moncho-Santonja M, Defez B, Candeias C, Rocha F, Peris-Fajarnés G.   +5 more
europepmc   +1 more source

Redefining macrophage phenotypes after spinal cord injury: An open data approach. [PDF]

Exp Neurol
Stapenhorst França F, Gensel JC.
europepmc   +1 more source

RxTrends: An R-based Shiny Application for Visualising Open Data on Prescribed Medications in Ireland. [PDF]

HRB Open Res
Hassan Ali A, Flood M, Kirke C, Mattsson M, Walsh ME, Wallace E, Corrigan D, Fahey T, Boland F, Moriarty F.   +9 more
europepmc   +1 more source

A novel blockchain-based clustering model for linked open data storage and retrieval. [PDF]

Sci Rep
Fateminasab SS, Bahrepour D, Tabbakh SRK.   +2 more
europepmc   +1 more source

Open Data Are Urgently Needed for One Health-Based Investigations: The Example of the 2024 <i>Salmonella</i> Umbilo Multi-Country Outbreak. [PDF]

Int J Environ Res Public Health
Mazzeo A, Mascolo C, Esposito M, Maiuro L, Rosati S, Sorrentino E.   +5 more
europepmc   +1 more source