Results 241 to 250 of about 8,433,168 (301)

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

The long head of the biceps tendon as a pedicled autograft for acromioclavicular joint reconstruction: development of an arthroscopic technique. [PDF]

Surg Radiol Anat
Sevivas N, Pinto M, Sousa DN, Barreira D, Ângelo AC, Azevedo C, da Silva MR, Claro R, Espregueira-Mendes J, Pereira H, Lädermann A.   +10 more
europepmc   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source

Planning and delivering co-creation workshops: practical lessons from digital health device design. [PDF]

Front Digit Health
McConnell-Trevillion A, Webb L, Ju W, Mitra S, Baillie L, Nazarpour K.   +5 more
europepmc   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Redesigning Computer-aided Design and Manufacturing Guides for Mandibular Reconstruction: Dental Reference Cap and Synchronized Screw-Hole Guides. [PDF]

Plast Reconstr Surg Glob Open
Yen CH, Lee JJ, Wee SJ.
europepmc   +1 more source

Can a fluorescent imaging device (MolecuLight) function as an adjunct to surgical debridement during revision knee arthroplasty for periprosthetic infection in a tertiary centre: a feasibility study. [PDF]

BMJ Open
Archer JE, Adlan A, Sumathi V, Stevenson J.   +3 more
europepmc   +1 more source

Flow-Through Lateral Arm Flap With Vein Grafting for Repairing Circumferential Thumb Soft-Tissue and Segmental Vascular Defects. [PDF]

Plast Reconstr Surg Glob Open
Liu R, Xiao Y.
europepmc   +1 more source

Liposomal bupivacaine versus standard ropivacaine for pain control in adults receiving continuous supraclavicular brachial plexus blocks for open elbow arthrolysis: study protocol for a randomised controlled non-inferiority clinical trial. [PDF]

BMJ Open
Luo T, Zheng S, Zhao Y, Yang X, Li X, Ji Y, Wang Y, Tang H, Xiao R, Zhang W, Li T, Wang G, Yuan Y.   +12 more
europepmc   +1 more source