Results 191 to 200 of about 40,814,819 (270)

From empirical imprinting to programmable synthetic receptors: a perspective on data science and machine learning for molecularly imprinted polymers.

Polym Chem
Alsholi A, Tiwari S, Zhang J, Peeters M.
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Low-Risk Basal Cell Carcinoma: Surgery First, but Not Surgery Only-Toward Protocolised Active Surveillance. [PDF]

Exp Dermatol
De Giorgi V, Perillo G, Cecchi G, Fazzari F, Zuccaro B.   +4 more
europepmc   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Association between infections and frailty: a systematic review protocol. [PDF]

BMJ Open
Brunetti AP, Baothman M, Asare K, Mansfield KE, Warren-Gash C.   +4 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Sudden Unexpected Death in Infancy: Two European Models, One Diagnostic Imperative. [PDF]

Acta Paediatr
Pititto F, Marrone M, Bellacicco R, Paladini E, Pulin G.   +4 more
europepmc   +1 more source