Results 51 to 60 of about 502 (208)

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Recurrent hepatocellular carcinoma treated by laparoscopic non-anatomical liver resection via the retroperitoneal approach: a case report

Frontiers in Surgery
BackgroundRepeat laparoscopic hepatic resection is an important treatment for recurrent hepatocellular carcinoma. However, intra-abdominal adhesions from prior open surgery and poor exposure of posterior segment lesions significantly increase surgical ...
Kecheng Zhang, Yang Liu, Bing Liu, Ruiliang Ge   +3 more
doaj   +1 more source

Hepatic resection is associated with reduced postoperative opioid requirement

Journal of Anaesthesiology Clinical Pharmacology, 2016
Background and Aims: Postoperative pain can significantly affect surgical outcomes. As opioid metabolism is liver-dependent, any reduction in hepatic volume can lead to increased opioid concentrations in the blood.
Caitlyn Rose Moss, Julia Christine Caldwell, Babatunde Afilaka, Khaled Iskandarani, Vernon Michael Chinchilli, Patrick McQuillan, Amanda Beth Cooper, Niraj Gusani, Dmitri Bezinover   +8 more
doaj   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Safety and efficacy of laparoscopic repeat liver resection and re-operation for liver tumor

Scientific Reports, 2021
Laparoscopic liver resection (LLR) has been reported as a safe, minimally invasive, and effective surgery for the management of liver tumor. However, the efficacy and safety of laparoscopic repeat liver resection (LRLR) for recurrent liver tumor are ...
Koki Takase, Takuya Sakamoto, Yutaka Takeda, Yoshiaki Ohmura, Yoshiteru Katsura, Go Shinke, Kenji Kawai, Kohei Murakami, Yoshinori Kagawa, Toru Masuzawa, Atsushi Takeno, Taishi Hata, Kohei Murata   +12 more
doaj   +1 more source

Outcomes of liver resection in patients with colorectal liver metastases by laparoscopic or open surgery

Annals of Hepato-Biliary-Pancreatic Surgery, 2018
Colorectal cancer is found with liver metastases about 20-25% due to characteristics of cancer itself. Approximately 20% of liver metastases are found to be resectable. The objective of this study was to evaluate short-term outcomes of patients who received liver resection with colorectal cancer operation in our center by laparoscopic surgery or open ...
Shim, Jae-Ryong, Lee, Seung Duk, Park, Hyung-Min, Lee, Eung-Chang, Park, Boram, Han, Sung-Sik, Kim, Seong Hoon, Park, Sang Jae   +7 more
openaire   +2 more sources

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

The comparative analysis of clinical curative effect of laparoscopic hepatectomy and open resection for hepatic tumor

Zhongguo aizheng zazhi, 2017
Background and purpose: With the application of laparoscopy in the liver surgery increasingly widely used, the safety and feasibility of laparoscopic liver resection is gaining recognition gradually.
毛岸荣, 潘　奇, 赵一鸣
doaj  

Laparoscopic resection of hepatic alveolar echinococcosis: A single-center experience.

PLoS Neglected Tropical Diseases, 2022
IntroductionAlveolar echinococcosis (AE) remains a very rare disease requiring complete radical resection for curative treatment. While open approaches are common, safety and efficacy of laparoscopic resections remain unknown.MethodsThis is a single ...
Severin Gloor, Daniel Candinas, Guido Beldi, Anja Lachenmayer   +3 more
doaj   +1 more source

A Systematic Review and Meta‐Analysis of the Recurrence of Autoimmune Encephalitis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune encephalitis (AE) is a disease with a potential for recurrence, and patients receive immunotherapy to prevent it. However, there is no consensus on the duration of immunotherapy. This study aimed to determine the recurrence rate and identify the risk factors for AE to provide guidance on the duration of immunotherapy ...
Shangkai Bai, Sen Zhang, Haipei Zhang, Yating Zhang, Junhong Guo, Xiaoyan Yang   +5 more
wiley   +1 more source