Results 141 to 150 of about 1,007,234 (319)
Open Method of Coordination as a Europeanization Tool
Czech Journal of Political Science/Politologický časopis, 2009 The study analyzes the Open Method of Coordination phenomenon, which has over the last decade become a prominent representative of the “soft-law” approach to EU law-making and integration in general, with respect to its Europeanizing potential. It therefore seeks to answer the question whether it this method of governance can be considered a new (and ...
openaire +1 more source
FEBS Open Bio, EarlyView.Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid +3 more
wiley +1 more source
EU Legitimacy and Social Affiliation: A case study of engineers in Europe [PDF]
Analyses of European governance usually put the member states in the foreground, placing the citizens in the background. This article brings explanations of EU legitimacy down to the level of individuals.
Jan Gunnarsson
core
FEBS Open Bio, EarlyView.Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source
Legitimately Diverse, yet Comparable: On Synthesising Social Inclusion Performance in the EU [PDF]
The Open Method of Coordination (OMC) intends to enhance EU member states' performance with regard to social inclusion. In this context a set of commonly agreed performance indicators plays an important role.
Laurens Cherchye +2 more
core
FEBS Open Bio, EarlyView.Aged human bmMSCs are seeded in the scaffold. Osteoblastic induction can slightly increase cell's bone‐forming activity to produce bone‐like tissues, shown as the sporadic xylenol orange‐stained spots (the lower left image). Notably, pioglitazone plus EGCG co‐treatment dramatically increases cell's bone‐forming activity and bone‐like tissue production (
Ching‐Yun Chen +6 more
wiley +1 more source
FEBS Open Bio, EarlyView.We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley +1 more source
FEBS Open Bio, EarlyView.Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley +1 more source
Problems of the German Contribution to EU-SILC: A Research Perspective, Comparing EU-SILC, Microcensus and SOEP [PDF]
EU-SILC will become one of the most important statistical data sources for the Federal Government's future Poverty and Wealth Reports, for comparing Germany's position with those of the other EU member states in the "open method of coordination", and for
Richard Hauser
core
FEBS Open Bio, EarlyView.Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li +8 more
wiley +1 more source