Results 241 to 250 of about 3,014,186 (301)

Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4‐Mediated Acute Hepatitis

Advanced Science, EarlyView.
This study identifies hepatocyte‐derived BDNF as an endogenous TLR4 antagonist that alleviates acute hepatitis. BDNF is downregulated in hepatocytes via REST‐mediated transcriptional repression during ALI/ALF. Mechanistically, BDNF binds to TLR4 on macrophages to suppress inflammation.
Weiwei Zhu, Yaqian Cui, Yongqiang Zhou, Yihui Zheng, Lijiang Huang, Leiming Jin, Qianhui Zhang, Pan Chen, Mengsha Lin, Jiaxi Ye, Yongqiang Xiong, Joo Young Huh, Xiang Hu, Xiaokun Li, Wu Luo, Guang Liang   +15 more
wiley   +1 more source

Commentary: Complex Attention-Deficit Hyperactivity Disorder is Inherently Intersectional. [PDF]

J Dev Behav Pediatr
Loe IM, Spinks-Franklin A.
europepmc   +1 more source

Persistently Increased Expression of PKMzeta and Unbiased Gene Expression Profiles Identify Hippocampal Molecular Traces of a Long‐Term Active Place Avoidance Memory and “Shadow” Proteins

Advanced Science, EarlyView.
Protein complexes like KIBRA‐PKMζ are crucial for maintaining memories, forming month‐long protein traces in memory‐tagged neurons, but conventional RNA‐seq analysis fails to detect their transcript changes, leaving memory molecules undetected in the shadows of abundantly‐expressed genes.
Jiyeon Han, Alejandro Grau‐Perales, Rayna M. Harris, Edith Lesburguères, Hsin‐Yi Kao, Asit Pal, Juan Marcos Alarcon, Todd C. Sacktor, Stefano Martiniani, Hans A. Hofmann, André A. Fenton   +10 more
wiley   +1 more source

Policy on Paper compared with Policy in Practice: A Study of Healthy Default Beverage Implementation and Enforcement in the United States. [PDF]

Curr Dev Nutr
Sundermeir SM, Winkler MR, Davis JN, Mack A, Falbe J, Fuster M.   +5 more
europepmc   +1 more source

Beyond Extracellular Vesicle (EV) Hype: Practical Solutions and Remaining Hurdles in EV Research, Manufacturing, and Clinical Translation

Advanced Science, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are nanoscale mediators of intercellular communication with diverse molecular cargoes that reflect their cell of origin. Advances in isolation, detection, and single‐particle analytics have revealed increasing molecular and functional heterogeneity, while exposing limitations in how EV identity and activity are ...
David J. Lundy, Zoe L. Chau, Sheng‐You Chen, Nanami Fujisawa, John J. Hill, Barnett M. Hsu, Joanne K. Liu, Karol W. Mai, James J. Lai   +8 more
wiley   +1 more source

Strengthening Pandemic Preparedness: A Thematic Analysis of Frontline Healthcare Workers' Perspectives During the First Wave of the COVID-19 Pandemic in Aotearoa New Zealand: A Reflexive Thematic Analysis. [PDF]

Health Sci Rep
Pirker T, Al-Busaidi IS.
europepmc   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Labeling messages as AI-generated does not reduce their persuasive effects. [PDF]

PNAS Nexus
Gallegos IO, Shani C, Shi W, Bianchi F, Gainsburg I, Jurafsky D, Willer R.   +6 more
europepmc   +1 more source

Artificial intelligence policies in neurology journals: a cross-sectional analysis. [PDF]

Front Neurol
Kirby K, Calvert N, Rowsey K, Brassfield J, Gardner T, Crotty P, Young A, Tran A, Ford AI, Vassar M.   +9 more
europepmc   +1 more source