Results 51 to 60 of about 129,517 (260)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Study of Community Perceptions of Green Open Spaces in Samarinda City

Journal of Mathematics Instruction, Social Research and Opinion
Green Open Space (GOS) in Samarinda City plays an important role as an ecological buffer, recreational facility, and public social space. However, variations in quality, facilities, and management have raised concerns about public comfort and the use of
Danish Naira Irawan, Yulian Widya Saputra, Aisyah Trees Sandy, Rahmadi Rahmadi   +3 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Campus Commons: Analysis of IIT Patna’s Public open Spaces

Qubahan Academic Journal
The Public open spaces offer amenities including areas for social interaction and physical activity, which are crucial for the overall wellness of society and the enhancement of living quality.
Nazish Abid, Mazharul Haque
doaj   +1 more source

Evolvement of Public Open Spaces in Historical Environments of Yerevan City

MATEC Web of Conferences, 2016
In this article the role of public open spaces in Yerevan city as well as their correct and literate organisation from an architectural and planning perspective are studied and evaluated.
Mamyan Zaruhi, Aloyan Artyom, Kartashyan Tatevik   +2 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

The Atmosphere in Open Public Spaces

, 2018
Introduction: A space’s atmosphere is an important factor in how that space is experienced. In fact, festival visitors consider the atmosphere as the most important factor in how they experience a festival (Van Vliet 2012). Atmosphere is also what distinguishes physical shops from online web shops (Van Vliet, Moes & Schrandt 2015).
van Vliet, Harry, Suurenbroek, Frank, Nio, Ivan, de Waal, Martijn   +3 more
openaire   +2 more sources

The Alignment of Public Open Space Elements with Visitor Motivation in the Musi Riverfront Public Open Space

Archvisual: Jurnal Arsitektur dan Perencanaan
Public open spaces are considered successful when they are continuously visited and provide tangible benefits to their users. Individuals’ intentions to visit a place, including public open spaces, are driven by internal motivations, whereas the choice of a specific destination is influenced by the elements present within the space.
Almira Ulfa, null Sri Lilianti Komariah, null Fuji Amalia, null Rizka Drastiani, null Rakhmat Fikran Zuhair   +4 more
openaire   +1 more source