Results 51 to 60 of about 134,952 (255)

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Multipartite quantum correlations in open quantum systems

New Journal of Physics, 2013
In this paper we present a measure of quantum correlation for a multipartite system, defined as the sum of the correlations for all possible partitions. Our measure can be defined for quantum discord (QD), geometric quantum discord (GQD), or even by the entanglement of formation (EOF).
Ma, Zhihao, Chen, Zhihua, Fanchini, Felipe Fernandes   +2 more
openaire   +4 more sources

Advances in Sequential Measurement and Control of Open Quantum Systems

Proceedings, 2019
Novel concepts, perspectives and challenges in measuring and controlling an open quantum system via sequential schemes are shown. We discuss how similar protocols, relying both on repeated quantum measurements and dynamical decoupling control pulses, can
Stefano Gherardini, Andrea Smirne, Matthias M. Müller, Filippo Caruso   +3 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Bound on the distance between controlled quantum state and target state under decoherence

Journal of Physics Communications
To implement quantum information technologies, carefully designed control for preparing a desired state plays a key role. However, in realistic situation, the actual performance of those methodologies is severely limited by decoherence.
Kohei Kobayashi
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Realization of controllable open system with NMR

New Journal of Physics, 2019
An open quantum system is now attracting much attention because a quantum device such as quantum computers and quantum sensors is an emerging technology. Here, we present a model of the open system that shows either time-homogeneous Markovian relaxations
Le Bin Ho, Yuichiro Matsuzaki, Masayuki Matsuzaki, Yasushi Kondo   +3 more
doaj   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Bottomonium suppression in an open quantum system using the quantum trajectories method

Journal of High Energy Physics, 2021
We solve the Lindblad equation describing the Brownian motion of a Coulombic heavy quark-antiquark pair in a strongly coupled quark-gluon plasma using the highly efficient Monte Carlo wave-function method.
Nora Brambilla, Miguel Ángel Escobedo, Michael Strickland, Antonio Vairo, Peter Vander Griend, Johannes Heinrich Weber   +5 more
doaj   +1 more source