Results 41 to 50 of about 20,668,687 (256)

UK DRAFFT : a randomised controlled trial of percutaneous fixation with kirschner wires versus volar locking-plate fixation in the treatment of adult patients with a dorsally displaced fracture of the distal radius [PDF]

, 2011
Background: Fractures of the distal radius are extremely common injuries in adults. However, the optimal management remains controversial. In general, fractures of the distal radius are treated non-operatively if the bone fragments can be held in ...
Brown, Jaclyn, Costa, Matthew L., Lamb, S. E. (Sallie E.), Parsons, Nicholas R., Parsons, NR, Richard P Edlin, Achten, Juul, Edlin, Richard P., Achten, J, Rangan, A, Matthew L Costa, Costa Matthew L, Juul Achten, Jaclyn Brown, Rangan Amar, Edlin Richard P, Lamb, Sarah, Amar Rangan, Costa, ML, Edlin, RP, Sarah E Lamb, Achten Juul, Nick R Parsons, Parsons Nick R, Rangan, Amar, Lamb Sarah E, Brown, J, Brown Jaclyn, Lamb, SE   +28 more
core   +2 more sources

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Bladder incarceration following anterior external fixation of a traumatic pubic symphysis diastasis treated with immediate open reduction and internal fixation [PDF]

, 2008
Anterior pelvic ring disruptions are often associated with injuries to the genitourinary structures with the potential for considerable resultant morbidity. Herniation of the bladder into the symphyseal region after injury with subsequent entrapment upon
Mary C McCarthy, Herbenick Michael A, Michael A Herbenick, Michael J Prayson, Prayson Michael J, McCarthy Mary C, Finnan Ryan P, Ryan P Finnan   +7 more
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

sj-docx-6-hss-10.1177_15563316231204616 – Supplemental material for Arthroscopy-Assisted Open Reduction Internal Fixation Versus Conventional Open Reduction Internal Fixation in the Treatment of Ankle Fractures: A Systematic Review With Meta-Analysis

, 2023
Supplemental material, sj-docx-6-hss-10.1177_15563316231204616 for Arthroscopy-Assisted Open Reduction Internal Fixation Versus Conventional Open Reduction Internal Fixation in the Treatment of Ankle Fractures: A Systematic Review With Meta-Analysis by ...
Dimitrios Ntourakis (16890183), Melika Hajymiri (17284709), Theodoros Lytras (351836), Philip Manolopoulos (17284712), Marc Meyer-Pries (17284706)   +4 more
core   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Excision Versus Fixation of the Radial Head: A Comparative Study of the Functional Outcomes of the Two Techniques [PDF]

Journal of Clinical and Diagnostic Research, 2017
Introduction: The management of displaced and comminuted radial head fractures has been a matter of debate amongst surgeons for many years. Radial head excision formed the mainstay of surgical management of these injuries.
Sanath Kumar Shetty, Ashwin Shetty, Bijith Balan, Arjun Ballal, H.Ravindranath Rai, Anoop Hegde   +5 more
doaj   +1 more source

sj-docx-5-hss-10.1177_15563316231204616 – Supplemental material for Arthroscopy-Assisted Open Reduction Internal Fixation Versus Conventional Open Reduction Internal Fixation in the Treatment of Ankle Fractures: A Systematic Review With Meta-Analysis

, 2023
Supplemental material, sj-docx-5-hss-10.1177_15563316231204616 for Arthroscopy-Assisted Open Reduction Internal Fixation Versus Conventional Open Reduction Internal Fixation in the Treatment of Ankle Fractures: A Systematic Review With Meta-Analysis by ...
Dimitrios Ntourakis (16890183), Melika Hajymiri (17284709), Theodoros Lytras (351836), Philip Manolopoulos (17284712), Marc Meyer-Pries (17284706)   +4 more
core   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Temporary Bridging of Severe Medial Column Injury of the Foot using Internal Fixation

Journal of Orthopaedics, Trauma and Rehabilitation, 2014
Inadequate treatment of midfoot crush injury often leads to permanent disability. The principle of treatment is to restore foot column length and joint congruity while it is stable enough to allow an early rehabilitation.
Michael Siu-Hei Tse, Siu-Bon Woo
doaj   +1 more source