Results 171 to 180 of about 17,086,626 (304)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

open access: yesMolecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic   +15 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Open Jerusalem Panel at MESA 2015

open access: yes, 2015
MESA 2015, Denver (US), Panel n° 4125, Sunday November 22nd, 8:30-10:30: "Open Jerusalem! Towards a New Entangled History of Citadinité (1840-1940): Concepts, Methods and Archives" Organized by Vincent Lemire Supported by ERC Funded Project OPEN ...
Open Jerusalem
core  

Successful open repair of blunt traumatic thoracoabdominal aortic injury with concomitant L1/L2 fracture-dislocation. [PDF]

open access: yesJ Cardiothorac Surg
Kanazawa Y   +5 more
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

open access: yesMolecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin   +3 more
wiley   +1 more source

Opening Open Jerusalem: OJ International Workshop

open access: yes, 2018
The project’s international workshop, entitled “Opening Open Jerusalem: Tracing Historical Paths through the Jerusalem Archives Digital Platform,” takes place at the Ca’ Foscari University of Venice on 8–9 October 2018.
Open Jerusalem
core  

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