Results 151 to 160 of about 70,104,016 (248)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

<i>ERJ Open Research</i> in 2026: progress and future directions. [PDF]

ERJ Open Res
Song WJ, Frost F.
europepmc   +1 more source

What senior academics can do to support reproducible and open research: a short, three-step guide. [PDF]

BMC Res Notes, 2022
Kowalczyk OS, Lautarescu A, Blok E, Dall'Aglio L, Westwood SJ.   +4 more
europepmc   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

CVSim: An Open-Source Cardiovascular Simulator for Teaching and Research

, 2009
CVSim is a lumped-parameter model of the human cardiovascular system that has been developed and used for research and for teaching quantitative physiology courses at MIT and Harvard Medical School since 1984.
Moody, George B., Mark, Roger Greenwood, Heldt, Thomas, Mukkamala, Ramakrishna   +3 more
core  

An open-source high-precision hive for long-term honeybee observation and research

Biology Open
Jiří Ulrich, Martin Stefanec, Tomáš Rouček, Laurenz Alexander Fedotoff, Harald Pascher, Zdeněk Rozsypálek, Thomas Schmickl, Tomáš Krajník   +7 more
doaj   +1 more source

Transparency in reporting frameworks in Osteoarthritis and Cartilage Open: Research designs and value streams. [PDF]

Osteoarthr Cartil Open
Christensen R, Haugegaard T, Madry H.
europepmc   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

West Nile virus: epidemiology, prevention, clinical features, diagnosis, treatment, and open research questions. [PDF]

Ann Med
Zerbato V, Rossi B, Di Bella S, Bartalucci C, Cerchiaro M, Da Re D, Dentone C, Sepulcri C, Marini G, Delfino E, Sang Tran A, Di Biagio A, Giacobbe DR, Bassetti M.   +13 more
europepmc   +1 more source

Human-Inspired Optimization Algorithms: Theoretical Foundations, Algorithms, Open-Research Issues and Application for Multi-Level Thresholding. [PDF]

Arch Comput Methods Eng, 2022
Rai R, Das A, Ray S, Dhal KG.
europepmc   +1 more source