Results 121 to 130 of about 9,393,136 (292)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Helmholtz Open Science Briefing: 2nd Helmholtz Open Science Forum “Open Science and Transfer”

On January 22, 2024 the Helmholtz Open Science Office hosted the Second Helmholtz Open Science Forum on the topic of Open Science and Transfer. The online event addressed various aspects and issues around the interplay of Open Science, Technology Transfer, Knowledge Transfer and Citizen Science at the Helmholtz Association.
Meistring, Marcel, Bertelmann, Roland, Dallmeier-Tiessen, Suenje, Engert, Tobias, Fischer, Janine, von Gönner, Julia, Liedtke, Christin, Saleh, Zahra, Stirling, Julian, Voroshnin, Vladimir, Wenzel, Lisa   +10 more
openaire   +2 more sources

New science on the Open Science Grid [PDF]

, 2008
The Open Science Grid (OSG) includes work to enable new science, new scientists, and new modalities in support of computationally based research. There are frequently significant sociological and organizational changes required in transformation from the
Altunay, Mine, Avery, Paul, Bejan, Alina, Blackburn, Kent, Blatecky, Alan, Gardner, Rob, Kramer, Bill, Livny, Miron, McGee, John, Olson, Doug, Pordes, Ruth, Potekhin, Maxim, Quick, Rob, Roy, Alain, Sehgal, Chander, Wenaus, Torre, Wilde, Mike, Würthwein, Frank   +17 more
core  

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Fetal Brain Tumor Harboring a Unique ROCK1::BRAF Fusion

Pediatric Blood &Cancer, EarlyView.
Marllon Cindra Sant'Ana, Mariana Maschietto, Daniela Paz Leal, Ricardo de Santos de Oliveira, Mayara Ferreira Euzébio, Antonio Carlos dos Santos, Luciano Neder, Carlos Alberto Scrideli, Elvis Terci Valera   +8 more
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Is Open Science the Same as Open Source Science? [PDF]

, 2017
How open source hardware and software can help to level up open science into open research when used for both methods and tools in the research ...
González Delgado, Manuel Ángel, Hernández Díez, María Carmen, Llamas Bello, César, Vegas Hernández, Jesús María   +3 more
core   +3 more sources

Talking Open Data

, 2017
Enticing users into exploring Open Data remains an important challenge for the whole Open Data paradigm. Standard stock interfaces often used by Open Data portals are anything but inspiring even for tech-savvy users, let alone those without an ...
Neumaier, Sebastian, Savenkov, Vadim, Vakulenko, Svitlana   +2 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source