Results 151 to 160 of about 8,389,625 (348)
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Intellectual Property Rights and Market Dynamics [PDF]
Two opposite models are currently operating in the modern economy, the strong intellectual property rights (IPR) model, and the open source/open science model. They have traditionally been applied to alternative institutional contexts.
Fabrizio Cesaroni, Paola Giuri
core
An unrealistic image of science [PDF]
, 2007 Many UK secondary schools (ages 11-18) host Open Days for pupils in their final year of primary school education (age 10). At these events science teachers try, through the judicious use of a select number of practical tasks, to portray science as ...
Abrahams, I. Z.
core
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Connecting Research with Communities through Performative Social Science [PDF]
, 2012 A pioneer in Performative Social Science, Kip Jones makes a case for the potential of arts-based social science to reach audiences and engage communities.
Jones, Kip
core +1 more source
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
open science good science: a light intro to open science
, 2017 This talk is presented in Telkom University Literacy Day, 12 Sep 2017. The objective of this talk is to introduce open science to students and early career researchers.
openaire +1 more source
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
Biological Psychiatry: Global Open Science—Supporting Open Science and Global Diversity in Research
Biological Psychiatry Global Open Science, 2021 Deanna M. Barch
doaj +1 more source
Editorial Policy and the Dissemination of Scientific Knowledge on Open Access—Case Study: Science Communication Journals in Latin America [PDF]
Fernando Sánchez-Pita +2 more
openalex +1 more source