Results 161 to 170 of about 8,047,805 (354)
FEBS Letters, EarlyView.We achieved cytoplasmic delivery of non‐cell‐penetrating IgGs by grafting a single functional complementarity‐determining region 1 (CDR1) from the light chain variable region (VL) of the cell‐internalizable 3D8 antibody. The engineered IgG acquired cell‐penetrating ability while maintaining antigen affinity, highlighting CDR1 grafting as a promising ...
Yerin Jeon +5 more
wiley +1 more source
Open Science Practices are on the Rise: The State of Social Science (3S) Survey [PDF]
, 2020 Has there been meaningful movement toward open sci-ence practices within the social sciences in recent years? Discussions about changes in practices such as posting data and pre-registering analyses have been marked by controversy—including controversy ...
Birke, David +6 more
core
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
How to build an Open Science Monitor based on publications? A French perspective [PDF]
arXivMany countries and institutions are striving to develop tools to monitor their open science policies. Since 2018, with the launch of its National Plan for Open Science, France has been progressively implementing a monitoring framework for its public policy, relying exclusively on reliable, open, and controlled data.
arxiv
Bootstrapping the Open Science culture: The fellowship approach [PDF]
, 1970 Sigrid Fahrer +3 more
openalex +1 more source
, 2017 {"references": ["A. Huebl et al. openPMD 1.0.0: A meta data standard for particle and mesh based data, technical specification (CC-BY 4.0), November 2015, DOI:10.5281/zenodo.33624", "A. Huebl et al. On the Scalability of Data Reduction Techniques in Current and Upcoming HPC Systems from an Application Perspective, ISC 2017, arXiv:1706.00522", "H ...
Huebl, Axel +6 more
openaire +4 more sources
FEBS Letters, EarlyView.The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang +2 more
wiley +1 more source
A Book That Begs for a Science Open to Speak Outside its Customary Lines [PDF]
, 1983 F.M. Mealing
openalex +1 more source
Contextualizing Openness: Situating Open Science.
, 2019 Zenodo (2019).
Chan, Leslie +4 more
openaire +4 more sources
FEBS Letters, EarlyView.The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp +5 more
wiley +1 more source