Results 211 to 220 of about 8,810,905 (348)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

Reimagining open science for global health: Epistemic power and the pursuit of health equity. [PDF]

PLOS Glob Public Health
Rangel Teixeira A, Kleinlein R, Kalema NL, Agyemang GO, Senteio C, Celi LA, Agyemang S, Kebede MA.   +7 more
europepmc   +1 more source

Open Watershed Science by Design: Leveraging Distributed Research Networks to Understand Watershed Systems: Workshop Report

, 2019
James Stegen, Eoin Brodie, Kelly Wrighton, Paul Bayer, David Lesmes, Sujata R. Emani, J. W. Moerman   +6 more
openalex   +2 more sources

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Toward multiplex health: integrating complexity, normativity, and Open Science. [PDF]

Front Psychol
Qadir J, Maddah D, Qoronfleh MW, Senturk R.   +3 more
europepmc   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Open science falling behind in the era of artificial intelligence. [PDF]

Front Res Metr Anal
Pei G, Huang H.
europepmc   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Using Open Science Tools to Teach Environmental Sciences. [PDF]

Ecol Evol
Zuliani M, Lortie CJ.
europepmc   +1 more source

AgTC and AgETL: open-source tools to enhance data collection and management for plant science research [PDF]

Luis Vargas-Rojas, To‐Chia Ting, Katherine M. Rainey, Matthew Reynolds, Diane Wang   +4 more
openalex   +1 more source